Invitro-BA scientist

6 days ago

Bengaluru, India Syngene Full time

Job Title: Invitro ADME Bioanalyst

Job Location: Hyderabad

Department: Discovery Biology

At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and SOPs, in letter and spirit

Mandatory expectation for all roles as per Syngene safety guidelines

Overall adherence to safe practices and procedures of oneself and the teams aligned Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times. Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace. Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self. Compliance to Syngene’ s quality standards at all times.

Core Purpose of the Role:

Bioanalytical scientist familiar in handling HPLC and support ADME screening assays: Formulations analysis, solubility studies, stability studies, ectc. and understanding of LCMS in line with business needs.

Role Accountabilities

Optimization of test compounds and to develop high throughput, fit for purpose HPLC-UV methods to support ADME samples analysis: Formulations analysis, solubility studies, stability studies, ectc. Perform analysis of samples generated for the screening of compounds for ADME assays and Processing of different matrices/formulation samples of PK studies Good written and oral communication skills interacting with internal stakeholders Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system Preparation of protocols, reports and templates for responsible activities Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy Adhering to safety and quality policies laid by organization

Syngene Values

All employees will consistently demonstrate alignment with our core values

 Excellence

 Integrity

 Professionalism

Experience: Minimum 0 to 4 years of relevant industrial experience

Demonstrated Capability:

Hands-on experience in handling of LC-MS/MS systems is mandatory and experience on HRMS is advantageous Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assay samples analysis. Basic knowledge on Large molecule and Peptides analysis using LCMS/HRMS Should assist/deliver the scientific presentation in departmental journal club and write official Project reports Should be equipped with quality policies related to data management and data integrity

Education: M. Pharm in Pharmaceutical sciences/ Relevant master’s degree in pharmaceutical sciences or instrumentation

Skills and Capabilities:

Good communication skills

Strong problem-solving and handling skills

Team Player

Ability to learn/implement new assay in ADME and Analytical

Quality compliance skills

Behavioral / Managerial skills:

Demonstrated capabilities in leading a team and working in a matrix environment. Ability to rationally discuss data make data-driven decisions, and influence decisions to select optimal molecules for development. Ability to work in collaboration with a large inter-disciplinary team and assimilate data from various aspects. Excellent communication and presentation skills Experience managing multiple complex projects simultaneously requiring frequent communication, organizing/time management, and problem-solving skills Excellent interpersonal, communication, collaboration, analytical, and scientific project management skills Ability to work with senior management with professionalism and discretion

Equal Employment Opportunity:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.

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