Research & Development Head

10 hours ago

Dombivli, Maharashtra, India Three Pillars Staffing Solutions Full time ₹ 20,00,000 - ₹ 25,00,000 per year

Role & responsibilities

  • Identification of New Molecules with the best route of synthesis and safety
  • Management meetings for R&D and manufacturing approvals of upcoming and profitable molecules (API intermediates or Fine chemicals).
  • Brief literature survey and assessments for developing the best working synthetic route with optimization study and process validation for yield, purity and low cost.
  • Assigning work to the subordinates with weekly planning and weekly updates
  • Developing safe and scalable processes at R & D level by performing safety assessments.
  • Converting batch process to continuous flow.
  • Responsible for identification and audit for third-party manufacturing facility approval.
  • Synthesizing the molecules on mg to gram scale with process validation as well as scale-up studies.
  • Responsible for ISO certification as Auditee.
  • Any other work or assignment as assigned by the Management.
  • Identification of new API intermediates, speciality chemicals with potential feasibility in domestic as well as regulatory market.
  • Conduct Management meetings for R&D and manufacturing approvals of upcoming and profitable molecule (API intermediates or Speciality chemicals).
  • Guided a team of minimum 15 research associates including synthetic R&D, Tech transfer and ADL with daily reportings and quarterly reviews.
  • Brief literature survey using Reaxys, Smartchem and assessments for developing best working synthetic route with optimization study and process validation for yield, purity and low cost.
  • Develop safe and scalable process at R & D level to production scale by performing safety assessments.
  • Responsible for identification and audit for third party manufacturing facility approval.
  • Responsible for laboratory safety, risk assessment for process deviations.
  • Good Knowledge of interpretation of molecules by 1HNMR, 13C NMR, IR, HRMS and GCMS.
  • Responsible for reporting to international customers (US/UK/Japan).
  • Responsible for ISO certification and ISO Audits.
  • Responsible for planning & execution of lab trial & validation batches, pilot plant validation batches & commercial validation batches with subordinates.
  • Responsible for technology absorption & technology transfer review for new molecule from R&D to pilot plant & commercial plant.
  • Evaluation of safety data & critical process parameter identification during lab optimization, pilot plant & commercial batches.
  • Review pilot plant campaign & technology transfer campaign, providing technical support, planning resources, co-ordination with other department for successful execution.
  • Execution and evaluation of HAZOP study for new & existing process for scale-up, technology transfer, site transfer and plant transfer across the location.
  • Process de-bottlenecking and troubleshooting of plant problems, manufacturing issues with process and engineering control across the location.
  • Evaluation and execution of root cause analysis for OOT & OOS through historical data.
  • Responsible for process improvement, cycle time reduction, process de-bottlenecking for throughput improvement, solvent recovery & recycle improvement.
  • Drive various cost reduction initiatives in the facility like throughput improvement, process scale-up, process simplification, solvent recovery & recycle improvements, and yield improvement by engineering control without process change.

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