
Senior Bioinformatics Specialist
2 weeks ago
About Loopworm's Bioinformatics Initiative
Loopworm is at the forefront of recombinant protein production innovation. Our novel LoopBac platform leverages insects as miniature bio-factories, a paradigm shift from conventional cell culture methods. This cutting-edge technology enables complex protein production at significantly reduced costs and timelines.
We are on the cusp of a groundbreaking achievement and seek an exceptional Bioinformatics Scientist to spearhead our R&D efforts in this area. You will report directly to the VP of R&D and serve as the central point of expertise across multiple domains.
Key Responsibilities- Protein Production Optimisation Team: Provide DNA, gene, or protein sequence insights for any new protein of choice, coordinating with contractual gene synthesis partners for gene sequence validation and codon optimization.
- Genetic Engineering & Molecular Biology Team: Support comparative genomics and virus–host interaction studies to enhance the platform.
- Downstream Process Optimisation Team: Advise on recombinant protein–host protein interactions, protein tagging, and purification strategies.
- QA/QC & Assay Team: Recommend appropriate kits, antibodies, and assays through protein–protein interaction studies.
- Codon Optimization for Novel Insect Host Expression
- Promoter & Enhancer Sequence Identification and Prediction
- Viral Vector Stability and Sequence Optimization
- Post-Translational Modification (PTM) Mapping in Novel Insect Host
- In-Silico Screening for Expression Bottlenecks
- PhD/Master's: in Bioinformatics, Computational Biology, or a related field.
- 5 Years: hands-on experience running bioinformatics pipelines for Protein/DNA analysis.
- Expertise in genetics, genomics, proteomics, and protein modeling databases.
- Preferred coding background in Python, R, Perl (or similar), with ability to adapt and work with outsourced software developers.
- Experience in protein sequence analysis, codon optimization, and comparative genomics.
- Familiarity with AI tools in bioinformatics (preferred but not mandatory).
- Strong problem-solving skills and ability to work independently while coordinating with multiple teams.
- Sequence Analysis & Databases: NCBI, UniProt, Ensembl, KEGG, PDB
- Genomics & Alignment: BLAST, Clustal Omega, MUSCLE, MAFFT
- Protein Modeling: AlphaFold, Swiss-Model, PyMOL, Chimera
- Data Analysis: Bioconductor, Galaxy, Geneious
- AI/ML & Coding: TensorFlow/PyTorch (for bioinformatics), Python/R, Jupyter Notebooks
- Workflow Tools: Nextflow, Snakemake, or similar
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