Senior Bioinformatics Scientist

3 days ago

Bengaluru, Karnataka, India Loopworm Full time

About Loopworm

Loopworm is building the next frontier in recombinant protein production using our novel LoopBac platform — an optimised system that uses insects as miniature bio-factories instead of conventional cell culture methods. This game-changing technology enables complex protein production at a fraction of the cost and time.

We are on the verge of a major breakthrough, and we're looking for a Senior Scientist – Bioinformatics to join our R&D team and single-handedly drive our bioinformatics initiatives. You will report directly to the VP of R&D and act as the central point of expertise across multiple verticals.

Key Responsibilities

You will be the go-to bioinformatics expert, collaborating with cross-functional teams to enable faster, more accurate, and cost-effective recombinant protein production:

  1. Protein Production Optimisation Team – Provide DNA, gene, or protein sequence insights for any new protein of choice; coordinate with contractual gene synthesis partners for gene sequence validation and codon optimisation.
  2. Genetic Engineering & Molecular Biology Team – Support comparative genomics and virus–host interaction studies to enhance the platform.
  3. Downstream Process Optimisation Team – Advise on recombinant protein–host protein interactions, protein tagging, and purification strategies.
  4. QA/QC & Assay Team – Recommend appropriate kits, antibodies, and assays through protein–protein interaction studies.

What are the problem statements you would be working on

  • Codon Optimisation for Novel insect host expression
  • Promoter & Enhancer Sequence Identification and Prediction
  • Viral Vector Stability and Sequence Optimisation
  • Post-Translational Modification (PTM) Mapping in novel insect host
  • In-Silico Screening for Expression Bottlenecks

Required Skills & Experience

  • PhD/Master's in Bioinformatics, Computational Biology, or a related field.
  • 5 years of hands-on experience in running bioinformatics pipelines for Protein/DNA analysis.
  • Expertise in genetics, genomics, proteomics, and protein modelling databases.
  • Preferred coding background in Python, R, Perl (or similar), with ability to adapt and work with outsourced software developers.
  • Experience in protein sequence analysis, codon optimisation, and comparative genomics.
  • Familiarity with AI tools in bioinformatics (preferred but not mandatory).
  • Strong problem-solving skills and ability to work independently while coordinating with multiple teams.

Preferred Tools / Platforms

(Candidates with proficiency in any of the following — or equivalent alternatives — are encouraged to apply)

  • Sequence Analysis & Databases: NCBI, UniProt, Ensembl, KEGG, PDB
  • Genomics & Alignment: BLAST, Clustal Omega, MUSCLE, MAFFT
  • Protein Modelling: AlphaFold, Swiss-Model, PyMOL, Chimera
  • Data Analysis: Bioconductor, Galaxy, Geneious
  • AI/ML & Coding: TensorFlow/PyTorch (for bioinformatics), Python/R, Jupyter Notebooks
  • Workflow Tools: Nextflow, Snakemake, or similar

Why Join Us?

  • Be part of an India-first biotech innovation.
  • Work on a revolutionary platform with potential to disrupt multiple industries — biopharma, diagnostics, cosmetics, and more.
  • Collaborate with passionate scientists, engineers, and entrepreneurs.
  • Enjoy a fast-paced and innovation-driven culture.

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