Senior Bioinformatics Scientist

1 day ago

Bengaluru, Karnataka, India Loopworm Full time
About Loopworm

Loopworm is building the next frontier in recombinant protein production using our novel LoopBac platform — an optimised system that uses insects as miniature bio-factories instead of conventional cell culture methods. This game-changing technology enables complex protein production at a fraction of the cost and time.

We are on the verge of a major breakthrough, and we're looking for a Senior Scientist – Bioinformatics to join our R&D team and single-handedly drive our bioinformatics initiatives. You will report directly to the VP of R&D and act as the central point of expertise across multiple verticals.

Key Responsibilities

You will be the go-to bioinformatics expert, collaborating with cross-functional teams to enable faster, more accurate, and cost-effective recombinant protein production:

1. Protein Production Optimisation Team – Provide DNA, gene, or protein sequence insights for any new protein of choice; coordinate with contractual gene synthesis partners for gene sequence validation and codon optimisation.
2. Genetic Engineering & Molecular Biology Team – Support comparative genomics and virus–host interaction studies to enhance the platform.
3. Downstream Process Optimisation Team – Advise on recombinant protein–host protein interactions, protein tagging, and purification strategies.
4. QA/QC & Assay Team – Recommend appropriate kits, antibodies, and assays through protein–protein interaction studies.

What are the problem statements you would be working on

- Codon Optimisation for Novel insect host expression
- Promoter & Enhancer Sequence Identification and Prediction
- Viral Vector Stability and Sequence Optimisation
- Post-Translational Modification (PTM) Mapping in novel insect host
- In-Silico Screening for Expression Bottlenecks

Required Skills & Experience

- PhD/Master's in Bioinformatics, Computational Biology, or a related field.
- 5 years of hands-on experience in running bioinformatics pipelines for Protein/DNA analysis.
- Expertise in genetics, genomics, proteomics, and protein modelling databases.
- Preferred coding background in Python, R, Perl (or similar), with ability to adapt and work with outsourced software developers.
- Experience in protein sequence analysis, codon optimisation, and comparative genomics.
- Familiarity with AI tools in bioinformatics (preferred but not mandatory).
- Strong problem-solving skills and ability to work independently while coordinating with multiple teams.

Preferred Tools / Platforms

(Candidates with proficiency in any of the following — or equivalent alternatives — are encouraged to apply)

- Sequence Analysis & Databases: NCBI, UniProt, Ensembl, KEGG, PDB
- Genomics & Alignment: BLAST, Clustal Omega, MUSCLE, MAFFT
- Protein Modelling: AlphaFold, Swiss-Model, PyMOL, Chimera
- Data Analysis: Bioconductor, Galaxy, Geneious
- AI/ML & Coding: TensorFlow/PyTorch (for bioinformatics), Python/R, Jupyter Notebooks
- Workflow Tools: Nextflow, Snakemake, or similar

Why Join Us?

- Be part of an India-first biotech innovation.
- Work on a revolutionary platform with potential to disrupt multiple industries — biopharma, diagnostics, cosmetics, and more.
- Collaborate with passionate scientists, engineers, and entrepreneurs.
- Enjoy a fast-paced and innovation-driven culture.

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