Senior Manager

Job Title:

Senior Manager / Associate General Manager – Discovery Services

Location: Pune

Department: Discovery Research

Reporting to: Head – Discovery

About Enzene Biosciences

Enzene Biosciences Ltd., a subsidiary of Alkem Laboratories, is a technology-driven biotechnology company headquartered in Chakan, Pune. Enzene is at the forefront of biologics development and manufacturing, offering end-to-end capabilities from research and process development to clinical manufacturing of biosimilars, novel biologics, and complex injectables.

Enzene's state-of-the-art facility is equipped with advanced platforms for monoclonal antibody production, ADCs, fusion proteins, and peptides. With a focus on automation, digital integration, and global compliance, we are rapidly emerging as a strategic partner for the global biopharmaceutical industry.

Our Discovery Services division plays a key role in identifying and engineering first-in-class and best-in-class therapeutic molecules using advanced display technologies and AI-enabled screening platforms.

Role Overview

We are seeking a passionate and accomplished scientist to lead early discovery programs focused on phage and yeast display platforms. The role requires deep technical knowledge, program leadership, and strategic collaboration to translate display-generated leads into viable therapeutic candidates.

Key Responsibilities

• Lead and execute phage and yeast display discovery programs for antibody and peptide therapeutics.
• Design high-throughput screening strategies, selection protocols, and affinity maturation campaigns.
• Oversee library construction (naïve, synthetic, immune) and validation with appropriate QC measures.
• Drive characterization and ranking of hits using biophysical and biochemical techniques.
• Collaborate with internal teams including Protein Sciences, Bioinformatics, Preclinical, and Regulatory.
• Ensure project delivery against timelines, scientific objectives, and regulatory quality expectations.
• Supervise and mentor a team of scientists and research associates, fostering scientific growth.
• Support generation of technical documentation, presentations, IP filings, and regulatory dossiers.
• Stay abreast of emerging display technologies, industry trends, and peer-reviewed advancements.

Required Qualifications

• PhD in Biotechnology, Immunology, Protein Engineering, Molecular Biology, or related field.
• 8–12 years of experience in the biotech/pharma industry or academia (including postdoctoral work).
• Proven expertise in phage and/or yeast display, including library design, selection, and optimization.
• Strong command of antibody structure-function, epitope mapping, and affinity maturation principles.
• Proficiency in molecular biology (cloning, expression), protein purification, ELISA/SPR/BLI, and FACS.
• Experience leading research programs and cross-functional teams.
• Familiarity with the biologics development pipeline, including regulatory expectations, is preferred.
• Strong communication, project management, and scientific documentation skills.

Preferred Skills

• Exposure to next-generation sequencing (NGS) for library diversity analysis.
• Familiarity with computational antibody design or structural modeling tools.
• Knowledge of alternative display systems (e.g., mammalian display, hybrid formats).
• Track record of scientific publications, patents, or conference presentations in relevant fields.

Why Join Enzene?

• Opportunity to lead innovative discovery programs in a global-scale biologics environment
• Work with cutting-edge platform technologies in antibody engineering and screening
• Collaborate with world-class scientific and operational teams in a rapidly growing biotech company
• Competitive compensation, supportive culture, and strong scientific leadership