Scientist - NBE Downstream Team

4 days ago

Hyderabad, Telangana, India Aurigene Pharmaceutical Services Full time ₹ 12,00,000 - ₹ 36,00,000 per year

Job Title: Protein Sciences Specialist - Purification/Downstream Processing

Education & Experience:

  • Masters degree in any area of Life Science.
  • 3-6 years of experience focusing on protein sciences, especially purification and downstream processing.

Business Understanding:

  • Ability to apply knowledge in protein purification processes relevant to biologics and biotech manufacturing.

Knowledge Requirements:

  • Strong fundamentals of protein structure and function.
  • Expertise in chromatography systems (e.g., AKTA) and various chromatography methods applied to different protein types.
  • Protein characterization and determination of physico-chemical properties.
  • Bio-conjugation techniques including cysteine conjugation, lysine conjugation, and linker technologies.
  • Protein stability analysis in discovery setups.
  • Scale-up experience of protein purification up to gram quantities.
  • Handling challenging proteins such as membrane proteins and multi-subunit proteins.
  • Experience with inclusion body refolding.

Roles & Responsibilities:

  • Execute protein purification and downstream processing workflows using chromatographic methods.
  • Perform protein characterization and stability studies to ensure quality and functionality.
  • Optimize and scale up purification processes for diverse proteins including complex membrane proteins.
  • Apply bio-conjugation methods as required in process development.
  • Collaborate with cross-functional teams to support discovery and manufacturing objectives.
  • Ensure accurate documentation and compliance with safety and quality standards.
  • Support process improvement initiatives and contribute to technology transfer activities.
  • Mentor junior team members and facilitate knowledge sharing within the team.

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