
Manager / Sr. Manager - Downstream Processing, R&D
10 hours ago
Best fit profile
- Knowledge in handling and troubleshooting purification methods at small scale and pilot scale
- Various Chromatography techniques like Ion exchange, Affinity, HIC etc.
- Ultrafiltration – TFF (Hollow Fiber/Cassettes).
- Should be well versed with FPLC, AKTA- Process, AKTA- Pilot.
Responsibilities
- Purification method development, optimization, & execution for bacterial & viral vaccines.
- Experience in Cell lysis, different chromatography platform, TFF system, Filtration unit and other unit operations used in protein purification.
- Purification method optimization and development for protein expressing in E.coli and mammalian cell culture.
- Execution of In –House Calibration of AKTA System, spectrophotometer, Auto pipettes, Weighing balance and supervision of In –House Calibration of pH /conductivity meter.
- Execution of scale up & scale down experiment for purification of Vaccines and biologics to obtain high yield & quality product.
- Downstream Process development, optimization & scale up of different vaccine bulk (Dengue Vaccine, Hepatitis A Vaccine and E.coli, BPBC /CEPI Vaccine).
- Co-ordination with technology transfer of production process and prioritization of tasks and completion of those in a timely manner.
- Any other responsibilities as assigned by R&D Head.
- Literature, research paper review and its implementation of new ideas.
- Preparation of process development report, process consistency report as per timelines.
- Preparation of SOPs, BPRs, protocol report and other documents required for R &D related activities
- IQ, OQ and PQ of new equipment's to be installed in downstream processing area.
Qualifications
- PhD/M.SC in Biotechnology.
- Having experience in Down Stream process (Protein Purification).
- Preferably from R&D setup.
Experience
Post PhD - 8+ Years of experience
Post master's - 16+ Years of experience
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