Manager / Sr. Manager - Downstream Processing, R&D

3 days ago

Delhi, Delhi, India Panacea Biotec Full time ₹ 20,00,000 - ₹ 25,00,000 per year

Best fit profile

  • Knowledge in handling and troubleshooting purification methods at small scale and pilot scale
  • Various Chromatography techniques like Ion exchange, Affinity, HIC etc.
  • Ultrafiltration – TFF (Hollow Fiber/Cassettes).
  • Should be well versed with FPLC, AKTA- Process, AKTA- Pilot.

Responsibilities

  • Purification method development, optimization, & execution for bacterial & viral vaccines.
  • Experience in Cell lysis, different chromatography platform, TFF system, Filtration unit and other unit operations used in protein purification.
  • Purification method optimization and development for protein expressing in E.coli and mammalian cell culture.
  • Execution of In –House Calibration of AKTA System, spectrophotometer, Auto pipettes, Weighing balance and supervision of In –House Calibration of pH /conductivity meter.
  • Execution of scale up & scale down experiment for purification of Vaccines and biologics to obtain high yield & quality product.
  • Downstream Process development, optimization & scale up of different vaccine bulk (Dengue Vaccine, Hepatitis A Vaccine and E.coli, BPBC /CEPI Vaccine).
  • Co-ordination with technology transfer of production process and prioritization of tasks and completion of those in a timely manner.
  • Any other responsibilities as assigned by R&D Head.
  • Literature, research paper review and its implementation of new ideas.
  • Preparation of process development report, process consistency report as per timelines.
  • Preparation of SOPs, BPRs, protocol report and other documents required for R &D related activities
  • IQ, OQ and PQ of new equipment's to be installed in downstream processing area.

Qualifications

  • PhD/M.SC in Biotechnology.
  • Having experience in Down Stream process (Protein Purification).
  • Preferably from R&D setup.

Experience

Post PhD - 8+ Years of experience

Post master's - 16+ Years of experience

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