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Research Scientist-in-vitro

2 weeks ago

Ahmedabad Gujarat, India Piramal Enterprises Full time

Understand and implement new experiments as per Customer requirement to answer in vitro Biology query to support small molecule drug discovery and development projects from various global customers.
- Attend Customer call to understand the requirement, propose study design and costing details to your reporting manager.
- Develop, optimize, and validate biophysical, biochemical, and cell-based assay platforms for the hit identification, lead optimization and functional characterization of small molecules.
- Ensure to coach your team member during the above process.
- Robust and high-quality assays with efficient use of automation and instrumentation will be an advantage.
- Work with different biological assays such as GPCR, Kinase and MOA studies, offering integrated drug discovery support alongside chemistry and support functions for multiple client-based projects.
- Help to develop diverse In-Vitro target/mechanism assays, amenable for high throughput screening, surrounding different key cellular processes and signal transduction pathways.
- Strong experience of working with small-molecule drug discovery from a CRO/Drug Discovery company with an ability to efficiently handle time-bound and service-based projects.
- Should have strong technical knowledge with exceptional attention to detail.
- Understanding of basic molecular biology, cell biology and biochemistry experiments will be an advantage.
- Broad research experience in cell-free and cell-based assay development using mentioned technology/platform viz. DELFIA® (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay), Fluorescence, Fluorescence Polarisation (FP), Luminescence, TRF, TR-FRET & HTRF, Alpha Screen assays, Nano BRET, Electrochemiluminescence (ECL), Flow Cytometry, FLIPR, High content imaging, Live Cell Analysis. Knowledge on Surface Plasmon Resonance (SPR) technology will be an advantage.
- Experienced in development and validation of In-Vitro models for diverse diseases especially related to oncology, inflammation, immunology, neurology, metabolic disease etc.
- Experience working with board target classes -e.g., enzymes, GPCRs, transporters, ion channels, surface receptors, etc. across different therapeutic areas.
- Execute program objectives, meticulously record experimental data and observations on a timely basis in acceptable format, prepare technical reports, summaries, and quantitative and qualitative analyses in written form.
- Work both independently and as part of a collaborative team in multiple geographies to design, plan and execute experiments that support research activities and project goals.
- Clearly communicate the status of projects, challenges, results, and proposed paths forward across internal and external stakeholders.
- Participate in cross-functional team activities, regularly add value to research projects through creative ideas. - Demonstrate excellent oral and written communication skills.
- Work well within a fast-paced, dynamic, results
- and team-oriented start-up environment.
- Open to miniaturize the assay from 96WP to 384WP to 1536WP format for both cell-free and cell-based assays.
- Knowledge in the generation of stable cell lines required for cell-based assay development and Screening Curiosity, energy, creativity, and bravery with a strong desire to help to build the healthy culture at organization.
- Effectively manage numerous tasks/projects simultaneously to meet internal/external deadlines in coordination with team members by displaying Piramal Successes Factors such as Display Humility, Serves Customers, Commits and Delivers Results, Collaborates, Empowers and develops, Think Big.

In the three decades of its existence, Piramal Group has pursued a twin strategy of both organic and inorganic growth.

Driven by its core values, Piramal Group steadfastly pursues inclusive growth, while adhering to ethical and values-driven practices.

**Equal employment opportunity**

Piramal Group is proud to be an Equal Employment Opportunity and Affirmative Action employer. We do not discriminate based upon race, ethnicity, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, genetics, or other applicable legally protected characteristics.

We base our employment decisions on merit considering qualifications, skills, performance, and achievements. We endeavor to ensure that all applicants and employees receive equal opportunity in personnel matters, including recruitment, selection, training, placement, promotion, demotion, compensation and benefits, transfers, terminations, and working conditions, including reasonable accommodation for qualified individuals with disabilities as well as individuals with needs related to their religious observance or practice.

**Piramal Pharma Solutions (PPS) **is a Contract Development and