Dmpk (Pre-formulations) - Research Scientist

3 days ago

Bengaluru, India Jubilant Biosys Full time

**DMPK (PRE-FORMULATIONS)**

**RESEARCH SCIENTIST**

**Educational qualifications
M.Pharm (Pharmaceutics)/ Ph.D (Pharmacy)

**Years of experience
8-10 yrs

**Key Responsibilities
Read and understand client pre-formulation
requirements

Solid State and Solution State
Characterization (interpretation of DSC, TGA
and pXRD etc. data)

Solubility assessment in Aqueous and
Organic solvents simulated intestinal and
gastric Medias.

Bioavailability enhancement of compounds

Excipient Compatibility Studies

Preclinical formulation development of NCEs
for pharmacokinetic, toxicology, & in vivo
efficacy studies.

Ability to work with wide variety of
excipients, API and dosage forms

Hands-on experience in strategy to come up
with pharmaceutically acceptable salts for
NCEs and their characterization and
interpretation of the data to propose the
suitable salt.

Should know the know-how of various
formulations combinations to address the
solubility issues for various routes to perform
PK studies in preclinical species.

Should be able to develop dosage forms for
therapeutic areas like oncology, metabolic
disorders, inflammation etc.

Should be able to develop HPLC-UV based
methods for conducting formulation analysis
under GLP and Non-GLP modes

Good knowledge of chromatography

Preparation of documents such as SOP’s for

**DMPK (PRE-FORMULATIONS)**

**RESEARCH SCIENTIST**

Laboratory instruments and reports for
preformulation studies.

**Experience required
Good scientific knowledge about the role of
pre-formulation in small molecule discovery.

Basic knowledge of pharmacokinetics.

Knowledge of various excipients and their
permissible limits in preclinical and clinical
setups.

Handling of HPLC-UV/PDA

Liquid chromatography.

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