Dmpk (Pre-formulations) - Ra/sra
2 days ago
**DMPK (PRE-FORMULATIONS)**
**RESEARCH ASSOCIATE/ Sr. RESEARCH ASSOCIATE**
**Educational qualifications**
M.Pharm (Pharmaceutics)
**Years of experience**
3-8 yrs
**Key Responsibilities**
- Read and understand client pre-formulation
requirements
- Solid State and Solution State
Characterization (interpretation of DSC, TGA
and pXRD etc. data)
- Solubility assessment in Aqueous and Organic
solvents simulated intestinal and gastric
Medias.
- Bioavailability enhancement of compounds
- Excipient Compatibility Studies
- Preclinical formulation development of NCEs
for pharmacokinetic, toxicology, & in vivo
efficacy studies.
- Ability to work with wide variety of excipients,
API and dosage forms
- Hands-on experience in strategy to come up
with pharmaceutically acceptable salts for
NCEs and their characterization and
interpretation of the data to propose the
suitable salt.
- Should know the know-how of various
formulations combinations to address the
solubility issues for various routes to perform
PK studies in preclinical species.
- Should be able to develop dosage forms for
therapeutic areas like oncology, metabolic
disorders, inflammation etc.
- Should be able to develop HPLC-UV based
methods for conducting formulation analysis
under GLP and Non-GLP modes
- Good knowledge of chromatography
**DMPK (PRE-FORMULATIONS)**
**RESEARCH ASSOCIATE/ Sr. RESEARCH ASSOCIATE**
- Preparation of documents such as SOP’s for
Laboratory instruments and reports for
preformulation studies.
**Experience required**
- Good scientific knowledge about the role of
pre-formulation in small molecule discovery.
- Basic knowledge of pharmacokinetics.
- Knowledge of various excipients and their
permissible limits in preclinical and clinical
setups.
- Handling of HPLC-UV/PDA
- Liquid chromatography.
-
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