Process Optimization Specialist

6 days ago

Bengaluru, Karnataka, India beBeeRecombinant Full time ₹ 20,00,000 - ₹ 25,00,000
**Purification Process Leader**

Loopworm is pioneering a breakthrough in recombinant protein production with our novel platform—using insects as miniature biofactories instead of conventional cell culture systems.

This disruptive approach offers cost-effective, scalable, and sustainable protein manufacturing for applications in life sciences and beyond.

Job Description:

We are looking for a Principal Scientist to lead our Downstream Process Optimisation & Protein Purification team. This leadership role will have direct impact on taking recombinant proteins from R&D scale to commercial manufacturing.

The successful candidate will oversee budget planning, strategy, and execution for downstream R&D activities. They will implement and validate virus removal/inactivation steps to meet global regulatory standards.

They will also translate research protocols to commercial-scale processes, collaborating closely with the commercial production team. Additionally, they will establish and maintain robust R&D processes, ensuring timelines and milestones are met.

The candidate will participate in recruitment, training, and development of team members.

Requirements:
  • PhD or Master's degree in Biotechnology, Bioprocess Engineering, Biochemistry, or related field.
  • 7+ years (PhD) or 10+ years (Master's) of industry experience in Recombinant Protein Purification and Downstream Processing.
  • Proven track record of scaling up purification processes from R&D to commercial manufacturing.
  • Experience in working with complex eukaryotic expression systems—preference for candidates with insect-based expression experience.
  • Exposure to IP processes and working with legal/IP teams.
Key Skills:

Hands-on experience with Chromatography Systems—AKTA or equivalent FPLC/HPLC systems for affinity, ion exchange, hydrophobic interaction, and size exclusion chromatography.

Tangential Flow Filtration (TFF) / Ultrafiltration Units for protein concentration, buffer exchange, and diafiltration at R&D and pilot scale.

Virus Removal & Inactivation Equipment for depth filtration units, virus filtration modules, and chemical inactivation setups.

Bioreactor Harvest & Clarification Systems for continuous and batch clarification units suitable for insect biomass processing.

Clean-In-Place (CIP) & Steam-In-Place (SIP) Systems for maintaining GMP compliance in purification operations.

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