Specialist - Antibody Discovery

2 days ago

New Delhi, India Aurigene Pharmaceutical Services Limited Full time

Role : Specialist – Antibody Discovery Company:Aurigene Pharmaceutical Services Ltd Location:HyderabadAbout the Role We're looking for an experiencedSpecialist – Antibody Discoveryto join our team in Hyderabad. In this seniorindividual contributorrole, you will lead the end-to-end execution of antibody discovery and upstream biologics activities, managing a sub-team within the Antibody Discovery group. Reporting to the Antibody Discovery Lead, you will be responsible for strategy alignment, resource management, and risk mitigation, while ensuring the successful delivery of assigned programs.What You'll Do Program Leadership:Lead and manage assigned antibody discovery programs, aligning on plans, milestones, and risk mitigation with the Antibody Discovery Lead. Antibody Generation:Generate therapeutic, tool-grade, and anti-idiotypic antibodies utilizing platforms such ashybridoma, phage/yeast display, and single B-cell screening technologies. Cell Line Engineering:Drivecell engineeringfor recombinant cell lines using state-of-the-art techniques, includinglentiviral transduction, CRISPR/Cas9, and traditional transfection. Reagent and Clone Development:Oversee the generation of high-quality reagents (cell lines, recombinant proteins, antibodies) with robust documentation (SOPs/ELN) and quality control. Execute and optimize clone development workflows and screening funnels for mAb/recombinant protein production. Upstream Operations:Manage upstream activities for large-molecule discovery, covering mammalian cell culture from shake flasks to bench-top bioreactors, ensuring compliance with safety and data integrity standards. Team & Project Management:Mentor and guide junior scientists/associates. Coordinate effectively withProtein Sciences, Analytics, Process Development, and Biologyto ensure timely program delivery. Client Interface:Interface with clients (under the Lead’s direction) to present technical updates, manage scope/timelines, and support proposals and Statements of Work (SoWs).What You'll Bring Education & Experience: PhDin Immunology, Molecular Biology, Biotechnology, or a related field. Minimum 5+ years of relevant experiencein antibody discovery and recombinant protein production. (Experience within aCRO/CDMO environment is preferred ). Key Skills: Deep expertise in multipleantibody discovery platforms(hybridoma, phage/yeast display, single B-cell). Hands-on proficiency incell line engineeringtechniques (lentiviral transduction, CRISPR/Cas9). Strong background inclone developmentandupstream operationsfor biologics. Proven abilities inteam leadership, project execution, and stakeholder/client management. Excellent documentation, data analysis, and problem-solving skills.

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