Sr. Site Reliability Engineer

At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Sr. Site Reliability Engineer

Let's do this. Let's change the world. In this vital role you will play a key role in building, scaling, and securing the platforms that underpin Amgen's global digital initiatives. This role focuses on ensuring the reliability, performance, and efficiency of cloud-native platforms while enabling development velocity and operational excellence.

You will be responsible for designing and operating infrastructure and shared platforms used across the enterprise, including CI/CD, observability, incident management, and collaboration systems. You will work extensively with containerized environments, handle multi-tenant Kubernetes platforms, and automate processes to improve resilience and reduce operational burden. This role requires deep technical depth, leadership skills, and the ability to drive initiatives across cross-functional teams and global stakeholders.

Platform Reliability Engineering

• Design, operate, and scale secure, highly available cloud-based infrastructure using Infrastructure as Code (IaC).

• Handle multi-tenant container orchestration environments with advanced access controls, workload isolation, and governance policies.

• Ensure enterprise CI/CD platforms are performant, secure, and optimized for high-throughput engineering teams.

Monitoring, Observability & Incident Management

• Build and handle observability platforms for full-stack visibility, leveraging metrics, logs, and traces.

• Define, implement, and continuously refine SLIs, SLOs, and error budgets for platform health and service performance.

• Automate incident response workflows, integrate with incident management platforms, and lead post-incident reviews and root cause analysis.

• Enterprise Platform Administration

• Operate and improve core engineering platforms (e.g., CI/CD, collaboration, knowledge sharing) to ensure availability, security, and ease of use.

• Automate platform provisioning, upgrades, access controls, and integration pipelines to reduce manual effort and improve consistency.

• Implement compliance, audit logging, and policy enforcement through code-driven governance models.

AI Adoption & Enablement

• Drive the adoption of AI/ML-based tools to enhance observability, incident prediction, remediation, and intelligent alerting.

• Evaluate and integrate AI-assisted automation platforms to reduce toil and improve operational efficiency.

• Partner with platform, security, and development teams to embed predictive analytics into dashboards, workflows, and root cause tooling.

• Champion a data-driven SRE practice by enabling thoughtful insights and anomaly detection across systems and platforms.

Leadership & Collaboration

• Serve as a technical thought leader and mentor within the SRE organization.

• Promote SRE principles and reliability culture across engineering teams.

• Collaborate with cross-functional stakeholders to influence architecture, roadmaps, and platform investment.

• Lead operational reviews and service health retrospectives, with a focus on continuous improvement.

• Participate in Agile and SAFe delivery processes—including sprint planning, stand-ups, retrospectives, and PI planning—to ensure security and platform reliability are embedded across development cycles.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The [vital attribute] professional we seek is a [type of person] with these qualifications.

Basic Qualifications:

• Doctorate degree / Master's degree / Bachelor's degree and 8 to 13 years in Computer Science, Information Technology, or a related technical field

• Demonstrated success operating cloud-native infrastructure in production environments

• Practical experience handling Kubernetes clusters and CI/CD environments at enterprise scale

• Exposure to global on-call or incident support rotations

• Excellent collaboration and communication skills across technical and non-technical teams

Preferred Qualifications:

Must-Have Skills:

• Deep experience with cloud platforms (AWS, Azure, or GCP), including services such as compute, networking, IAM, and VPC design

• Proven proficiency in Infrastructure as Code (IaC) using tools such as Terraform or CloudFormation

• Advanced skills in managing container orchestration platforms (e.g., Kubernetes), including workload isolation, resource quotas, and role-based access control

• Strong understanding of Linux system administration, process management, and system performance tuning

• Hands-on experience with CI/CD platforms and pipelines (build automation, artifact storage, environment provisioning, rollback strategies)

• Strong background in observability tooling, including Prometheus, Grafana, Dynatrace, and distributed tracing frameworks like OpenTelemetry or Jaeger

• Strong practical experience with incident management platforms and practices (e.g., alert routing, runbooks, escalation paths)

• Automation and scripting proficiency in languages such as Python, Go, or Bash

• Experience with configuration management tools like Ansible, Chef, or SaltStack

• Strong grasp of networking fundamentals, such as routing, DNS, OSI layers, load balancing, firewalls, TLS, and security groups

• Version control and collaboration workflows using Git and GitOps principles

• Experience with enterprise collaboration platforms, including provisioning, integration, and permission control

Good-to-Have Skills:

• Exposure to service mesh technologies (e.g., Istio, Linkerd) and zero-trust network concepts

• Familiarity with secrets management platforms (e.g., HashiCorp Vault, AWS Secrets Manager)

• Experience using incident response and chaos engineering tools (e.g., Gremlin, Chaos Mesh)

• Background in cost optimization, budgeting, and resource tracking (FinOps)

• Awareness of policy-as-code frameworks (e.g., OPA, Kyverno)

• Familiarity with feature flagging and progressive delivery tools (e.g., LaunchDarkly, Argo Rollouts)

• Integration experience with ticketing and change management platforms (e.g., ServiceNow, Jira)

• Understanding of compliance standards (e.g., HIPAA, GDPR, SOC 2) and how they apply to infrastructure operations

• Understanding of security and encryption technologies and authentication protocols such as OpenID, OIDC, OAuth, SAML, and LDAP

Professional Certifications (Preferred)

• Cloud DevOps Certification (AWS/Azure/GCP)

• Certified Kubernetes Administrator (CKA) or Security Specialist (CKS)

• CI/CD Platform Certification

• ITIL Foundation or equivalent service management certification

Soft Skills:

• High level of ownership and accountability for platform reliability

• Strong diagnostic and analytical capabilities with a bias for action

• Clear and confident communicator with an ability to influence without authority

• Passion for automation, operational excellence, and team mentorship

Shift Information: This position is an onsite role and may require working during later hours to align with business hours. Candidates must be willing and able to work outside of standard hours as required to meet business needs.

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we'll support your journey every step of the way.

In addition to the base salary, Amgen offers competitive and comprehensive Total Rewards Plans that are aligned with local industry standards.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.