Jr. Research Officer/ Research Officer

3 days ago

India Jai Research Foundation Full time

**Qualification**:
M. Pharm (Pharmacy), M.Sc. Life Science/ Biotechnology

**Experience**:
3-6 years.

**Skill sets required**:

- Assessing pharmacokinetic properties at various stages of drug development.
- Managing both immortalized and primary cell lines, good cell culture practices. Knowledge for maintaining cell viability, passage, and banking.
- Permeability assays using cell lines such as CaCO2 and MDCK-MDR1. Familiarity with relevant assays and the ability to interpret permeability data will be advantageous.
- Protein binding, CYP induction using primary human hepatocytes (PHH), time-dependent CYP inhibition, and assessing metabolic stability in human liver microsomes (HLM) and hepatocytes from different species.
- Familiarity with assessing hERG inhibition using patch clamp techniques.
- The technical skills should include hands-on experience with relevant laboratory equipment and software used in ADME research. Proficiency in data analysis and interpretation using tools such as LC-MS, HPLC, and other relevant platforms is expected.
- Knowledge of regulatory requirements and guidelines relevant to ADME studies is essential. You will play a key role in ensuring that all experiments are conducted in compliance with industry standards and regulatory expectations.
- This role offers a compelling opportunity for an experienced ADME Research Associate to leverage a wealth of techniques and methodologies, contributing significantly to multiple stages of the drug discovery process and advancing our objectives.

**Keywords**:

- Knowledge of cell culture - Cell based biochemical assays, High-throughput 96W, 384W.
- In vitro ADME Screening - Caco2, CYP Induction, MetID
- Assay development with cell free and cell based system.
- Instrumentations - Flow cytometry, patch clamp techniques, LCMS/MS.
- Molecular biology - Gene expression using RT-PCR.

**Other key skills**:

- MS Office and good communication skills.

**Position Vacant**:
1 (One).

**Package**:
Commensurate with qualification and experience.

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