Junior Research Fellow

2 days ago

Goa, India BITS PILANI GOA CAMPUS Full time

**Junior Research Fellow (JRF) position under DST-SERB funded project**

Applications are invited for the position of Junior Research Fellow in the Department of Chemical Engineering at BITS Pilani, K. K. Birla Goa Campus, Goa for DST-SERB sponsored research project titled “ **Determination of the protein folding, unfolding and refolding of spike glycoprotein of SARS Corona Virus-2 in Rubik’s Cube based statistical model and study of the thermodynamic interaction and kinetic behavior of the various equilibrated conformations with receptor of angiotensin converting enzyme-2 (ACE-2)”** **DST-SERB-POWER (FILENO.SPG/2021/004541).**

**Objectives of the Project**:
(i) Develop a Rubik’s Cube Model (RCM) based simulation technique to understand the folding, unfolding and refolding kinetics and various protein folding pathways of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV2) spike glycoprotein. (ii) Study of protein-folding dynamics of spike glycoprotein with statistical energy landscape theory (SELT) based stochastic model. (iii) Compare the similarity and dissimilarity between SELT and RCM model in details to understand the formation of various types of spike glycoprotein conformations and the efficiency of the Rubik’s Cube model. (iv) Understand the thermodynamics of molecular interaction between spike glycoprotein and the newly obtained equilibrated folded-unfolded-refolded conformations with receptor of angiotensin-converting enzyme-2 (ACE-2) using Grand Canonical Monte Carlo (GCMC) Simulation and calculation of the binding energy.

**Principal Investigator: Dr. Paramita Haldar**
**Broad area of Research: Molecular Modeling in Chemical Engineering**
**Duration of the project: 3 Years**
**Fellowship Amount (Rs.): Rs. 31,000 (1st Year and 2nd Year) and Rs. 35,000 (3rd Year)**

**Qualification (Compulsory)**:Post Graduate Degree in Basic Science (Physics or Chemistry or /Material Science) OR Post Graduate in Degree in Chemical Engineering or Bachelor's Degree in Chemical Engineering, Nanotechnology or Biotechnology.

**Qualification (Desired)**:
1. Scholars who are selected through National Eligibility Tests
- CSIR -UGC NET including lectureship (Assistant Professorship) and GATE.

2. The Selection process through National level examinations conducted by central Government departments and their agencies and Institutions such as DST, DBT, DAE, DOS, DRDO, MHRD, ICAR, IIT, IISc, IISER etc.'

**Qualification (Desired)**:Knowledge of programming (Matlab/Fortran/Python) and Molecular Dynamics

**Job Type**: Contractual / Temporary
Contract length: 36 months

**Salary**: ₹31,000.00 - ₹35,000.00 per month

Schedule:

- Day shift
- Monday to Friday

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