Senior Manager

Job Title:Senior Manager / Associate General Manager – Discovery ServicesLocation: PuneDepartment: Discovery ResearchReporting to: Head – DiscoveryAbout Enzene BiosciencesEnzene Biosciences Ltd. , a subsidiary of Alkem Laboratories , is a technology-driven biotechnology company headquartered in Chakan, Pune . Enzene is at the forefront of biologics development and manufacturing , offering end-to-end capabilities from research and process development to clinical manufacturing of biosimilars, novel biologics, and complex injectables .Enzene’s state-of-the-art facility is equipped with advanced platforms for monoclonal antibody production, ADCs, fusion proteins, and peptides. With a focus on automation, digital integration, and global compliance , we are rapidly emerging as a strategic partner for the global biopharmaceutical industry.Our Discovery Services division plays a key role in identifying and engineering first-in-class and best-in-class therapeutic molecules using advanced display technologies and AI-enabled screening platforms.Role OverviewWe are seeking a passionate and accomplished scientist to lead early discovery programs focused on phage and yeast display platforms . The role requires deep technical knowledge, program leadership, and strategic collaboration to translate display-generated leads into viable therapeutic candidates.Key ResponsibilitiesLead and execute phage and yeast display discovery programs for antibody and peptide therapeutics.Design high-throughput screening strategies , selection protocols, and affinity maturation campaigns.Oversee library construction (naïve, synthetic, immune) and validation with appropriate QC measures.Drive characterization and ranking of hits using biophysical and biochemical techniques.Collaborate with internal teams including Protein Sciences, Bioinformatics, Preclinical, and Regulatory .Ensure project delivery against timelines, scientific objectives, and regulatory quality expectations.Supervise and mentor a team of scientists and research associates, fostering scientific growth.Support generation of technical documentation, presentations, IP filings, and regulatory dossiers .Stay abreast of emerging display technologies, industry trends, and peer-reviewed advancements.Required QualificationsPhD in Biotechnology, Immunology, Protein Engineering, Molecular Biology , or related field.8–12 years of experience in the biotech/pharma industry or academia (including postdoctoral work).Proven expertise in phage and/or yeast display , including library design, selection, and optimization.Strong command of antibody structure-function , epitope mapping, and affinity maturation principles.Proficiency in molecular biology (cloning, expression), protein purification, ELISA/SPR/BLI, and FACS.Experience leading research programs and cross-functional teams.Familiarity with the biologics development pipeline , including regulatory expectations, is preferred.Strong communication, project management, and scientific documentation skills.⭐ Preferred SkillsExposure to next-generation sequencing (NGS) for library diversity analysis.Familiarity with computational antibody design or structural modeling tools.Knowledge of alternative display systems (e.g., mammalian display , hybrid formats).Track record of scientific publications, patents, or conference presentations in relevant fields.Why Join Enzene?Opportunity to lead innovative discovery programs in a global-scale biologics environmentWork with cutting-edge platform technologies in antibody engineering and screeningCollaborate with world-class scientific and operational teams in a rapidly growing biotech companyCompetitive compensation, supportive culture, and strong scientific leadership