Scientist - Peptide Process R &D
6 days ago
About the job Job Description Job Title: Scientist - Peptide Process R &D ( Proven track record in both SPPS and LPPS is highly desirable) Education & Experience : M.Sc./PhD Organic chemistry with experience on Peptide Process R &D with 3 to 15 years of experience. . 1.0 Position Summary We are seeking a highly skilled and motivated Research Scientist specializing in peptide chemistry. The ideal candidate will be responsible for the design, execution, optimization, and scale-up of synthetic peptides using both Solid-Phase Peptide Synthesis (SPPS) and Liquid-Phase Peptide Synthesis (LPPS) methodologies. This role requires hands-on expertise in various synthesis techniques, purification, and analytical characterization, as well as a strong commitment to safety, documentation, and project management within a dynamic R&D environment. 2.0 Key Responsibilities A. Peptide Synthesis & Development Design and execute multi-step synthesis of complex peptides (up to 30-40 mers) using manual and automated SPPS techniques. Demonstrate expertise with a wide range of peptide synthesis resins (e.g., 2-CTC, Rink Amide, Wang, Sieber) and select appropriate resins, protecting groups (Fmoc/Boc), coupling reagents, and solvents for target sequences. Perform advanced peptide modifications, including disulfide bridging, lactamization, and other cyclization strategies. Conduct peptide synthesis in solution phase (LPPS) utilizing both Fmoc and Boc protection strategies. Expertly carry out critical downstream processes, including resin cleavage, global deprotection, quenching, and product isolation. B. Instrumentation & Technology Operate, troubleshoot, and maintain automated peptide synthesizers. Utilize microwave peptide synthesizers (e.g., CEM Liberty Blue) to optimize reaction conditions and improve synthesis efficiency. Conduct synthesis at various scales using manual peptide reactors (1 L to 10 L). C. Purification & Analysis Purify crude peptides using preparative Reverse-Phase High-Performance Liquid Chromatography (RP−HPLC) and perform subsequent lyophilization. Interpret analytical data (e.g., HPLC, Mass Spectrometry) to assess reaction progress, purity, and yield, and generate trend data to guide process optimization. Conduct comprehensive literature surveys to support the development of novel and efficient synthesis strategies. D. Compliance, Safety & Documentation Maintain meticulous, real-time documentation of all experiments and results in an Electronic Lab Notebook (eLN). Ensure strict adherence to laboratory safety procedures to prevent incidents and maintain a safe working environment. Provide technical support for the technology
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Executive - API R&D
7 days ago
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Executive - API R&D
2 weeks ago
India Sun Pharmaceutical Industries - Full time ₹ 12,00,000 - ₹ 36,00,000 per yearJob Title:Executive/Sr Executive – API R&DBusiness Unit:R&D1 Regulatory AffairsJob GradeG12A / G11BLocation :BarodaAt Sun Pharma, we commit to helping you "Create your own sunshine"— by fostering an environment where you grow at every step, take charge of your journey and thrive in a supportive community.Are You Ready to Create Your Own Sunshine?As you...
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R&D Engineer
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R&D Engineer
2 weeks ago
Gujarat, Hazira Mfg Complex, India GT-L&T Energy Green Tech Limited Full time ₹ 8,00,000 - ₹ 24,00,000 per yearJob Title: R&D Engineer – Failure Mode AnalysisLocation: Hazira, GujaratReporting: Research Scientist, Green Tech Research & Innovation Department (GRID) Job Summary: The role of an R&D Engineer specializing in Failure Mode Analysis (FMA) involves identifying, analyzing, and resolving failure mechanisms in electrochemical systems, including energy...
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Electrochemical R&D Lead
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Research Scientist-R&D
3 weeks ago
Navi Mumbai, Mumbai, India Piramal Pharma Ltd Full timeJob Description Job Description Route Design & Development: - Develop novel and non-infringing synthetic routes for APIs and key intermediates. - Evaluate literature and patent landscape for synthetic feasibility and freedom to operate. Process Optimization - Conduct lab-scale synthesis and optimize reaction conditions for yield, purity, and scalability. -...
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Bengaluru, India BD Full timeJob Description Job Description Summary Seeking a high-level R&D Manager/Associate Staff Engineer who is a highly organized and results-driven professional with strong project management skills to lead complex, cross-functional initiatives. Primary focus of this position is to help execute, oversee and support strategic projects including Global UDI...
