Downstream Process Optimisation Specialist
5 days ago
About Loopworm
Loopworm is pioneering a breakthrough in recombinant protein production with our novel LoopBac platform — using insects as miniature biofactories instead of conventional cell culture systems. This disruptive approach offers cost-effective, scalable, and sustainable protein manufacturing for applications in life sciences, animal health, and beyond.
We are seeking an accomplished Principal Scientist - Downstream Process Optimisation & Protein Purification Leader. You will lead a team of 4 scientists and report to the VP of R&D. This role is at the forefront of biotechnology innovation, with direct impact on taking recombinant proteins from R&D scale to commercial manufacturing.
Key Responsibilities
- Lead, mentor, and manage the Downstream Process Optimisation & Protein Purification team, including setting individual KPIs.
- Oversight of downstream R&D activities strategy and execution.
- Design and optimise protein purification workflows for recombinant proteins expressed in complex eukaryotic systems (insect-based).
- Implementation and validation of virus removal/inactivation steps to meet global regulatory standards.
- Translation of research protocols to commercial-scale processes, collaborating closely with the commercial production team.
- Coordination with New Protein Production Optimisation Team – for upstream-downstream process integration.
- Establishment and maintenance of robust R&D processes, ensuring timelines and milestones are met.
- Contribution to IP strategy and protection of all downstream innovations.
- Participation in recruitment, training, and development of team members.
Required Skills & Experience
- PhD or Master's degree in Biotechnology, Bioprocess Engineering, Biochemistry, or related field.
- 7+ years (PhD) or 10+ years (Master's) of industry experience in Recombinant Protein Purification and Downstream Processing.
- Demonstrated expertise in virus removal or inactivation techniques.
- Proven track record of scaling up purification processes from R&D to commercial manufacturing.
- Strong leadership, people management, and cross-functional collaboration skills.
- Experience in working with complex eukaryotic expression systems – preference for candidates with insect-based expression experience.
- Exposure to IP processes and working with legal/IP teams.
- Exceptional problem-solving, analytical thinking, and communication skills.
Key Equipment & Machinery Proficiency
Hands-on experience required with:
- Chromatography Systems - AKTA or equivalent FPLC/HPLC systems for affinity, ion exchange, hydrophobic interaction, and size exclusion chromatography.
- Tangential Flow Filtration (TFF) / Ultrafiltration Units - Protein concentration, buffer exchange, and diafiltration at R&D and pilot scale.
- Centrifugation Systems - High-speed and ultracentrifuges for cell debris removal and clarification from insect biomass.
- Virus Removal & Inactivation Equipment - Depth filtration units, virus filtration modules (e.g., 20 nm filters), and chemical inactivation setups.
Benefits
- Be part of a India-first platform redefining how recombinant proteins are made.
- Lead a high-impact team in a fast-growing VC-backed biotech.
- Opportunity to work on patentable, globally relevant technologies.
- Contribute to a mission-driven company making protein production faster, cheaper, and greener.
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Bengaluru, Karnataka, India Loopworm Full timeAbout LoopwormLoopworm is pioneering a breakthrough in recombinant protein production with our novel LoopBac platform — using insects as miniature biofactories instead of conventional cell culture systems. This disruptive approach offers cost-effective, scalable, and sustainable protein manufacturing for applications in life sciences, animal health, and...
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Bengaluru, Karnataka, India Loopworm Full timeAbout Loopworm Loopworm is pioneering a breakthrough in recombinant protein production with our novel LoopBac platform — using insects as miniature biofactories instead of conventional cell culture systems. This disruptive approach offers cost-effective, scalable, and sustainable protein manufacturing for applications in life sciences, animal health, and...
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Bengaluru, Karnataka, India Loopworm Full timeAbout LoopwormLoopworm is pioneering a breakthrough in recombinant protein production with our novel LoopBac platform — using insects as miniature biofactories instead of conventional cell culture systems. This disruptive approach offers cost-effective, scalable, and sustainable protein manufacturing for applications in life sciences, animal health, and...
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Bengaluru, Karnataka, India Loopworm Full time ₹ 15,00,000 - ₹ 20,00,000 per yearAbout LoopwormLoopworm is pioneering abreakthrough in recombinant protein productionwith our novel LoopBac platform — using insects as miniature biofactories instead of conventional cell culture systems. This disruptive approach offers cost-effective, scalable, and sustainable protein manufacturing for applications in life sciences, animal health, and...
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Bengaluru, Karnataka, India Loopworm Full timeAbout LoopwormLoopworm is pioneering a breakthrough in recombinant protein production with our novel LoopBac platform — using insects as miniature biofactories instead of conventional cell culture systems. This disruptive approach offers cost-effective, scalable, and sustainable protein manufacturing for applications in life sciences, animal health, and...
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