Senior Computational Biologist

4 days ago

Pune, Maharashtra, India beBeeBioinformatician Full time ₹ 1,20,00,000 - ₹ 1,50,00,000
Transforming Biology through Causality

Synlico Inc. is at the forefront of transforming biology by leveraging causality to make cellular processes explainable, predictable, and engineerable.

Our AI platform employs machine learning & deep learning, causal discovery & inference, and single-cell bioinformatics.

We unravel the causal relationships between cells' intracellular activities and their responses in the patients' heterogeneous microenvironment, predicting how cell modulation alters its behavior in patients.

Our technology has a broad range of potential vertical applications in drug discovery, including target identification, therapy design, manufacturing, and biomarker discovery.

Job Responsibilities:
  • Conduct searches in public genomic databases (GEO, CellXGene, HumanCell Atlas).
  • Distinguish different functional genomics technologies and biological experimental methodologies to match our needs.
  • Understand necessary dataset qualifications.
  • Enter matching datasets to the database accurately with utmost attention.
  • Validate/cross-check new datasets to avoid duplicates or problems.
  • Optimize database structure to optimize information flow.
Requirements:
  • Ph.D graduate in computational biology, bioinformatics, single-cell biology, genomics, immunology, biomedical engineering, or a related field.
  • A strong technical focus and knowledge of genomics, molecular biology, and technologies such as qPCR and next-generation sequencing.
  • Demonstrated proficiency in analysis of large-scale transcriptomics data (especially scRNA-seq).
  • Experience identifying outliers for gene expression and splicing from RNA-seq data.
  • Experience working with relevant genomic databases and browsers and their annotations.
  • Proficiency in Git operations.
  • Strong coding and visualization skills using Python or R.
  • Experienced in data wrangling using pandas or tidyverse.
  • Skilled in Linux command-line interface (CLI) operations.
  • Attention to Detail: Ability to ensure accuracy and spot discrepancies or duplications for data entry and validation.
  • Dig to the bottom: Ability to track down correct data source and not be dissuaded by obstacles or incomplete information.
  • Critical Thinking: Ability to assess, analyze, and question information critically is essential.
  • Consistency: Ability to deliver steady and reliable results in a given time frame.
  • Good command of English speaking and writing.

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