Expert Small-Molecule Design Specialist

3 days ago


Rajkot, Gujarat, India beBeeDiscovery Full time ₹ 1,75,00,000 - ₹ 3,75,00,000
Senior Discovery Chemist

As a key member of our research team, you will play a vital role in advancing the development of novel small-molecule therapeutics. We are seeking an exceptional Senior Discovery Chemist to join us on this exciting journey.

Key Responsibilities:
  • Leverage your expertise in structure-based drug design and ligand pose evaluation to guide de novo small-molecule exploration and prioritization.
  • Collaborate with AI/deep learning engineers to refine molecular generation strategies using cutting-edge models such as REINVENT, Pocket2Mol, and diffusion-based 3D generators.
  • Apply comprehensive property filtering criteria including drug-likeness, ADMET, novelty, and selectivity to identify optimal compound candidates.
  • Integrate binding mode insights with biological context from our proprietary knowledge graph to align compounds with target mechanism-of-action.
  • Generate actionable compound selection lists for partner synthesis and in-vitro testing.
Requirements:
  • Ph.D. or M.Sc. in Medicinal Chemistry, Chemical Biology, Computational Chemistry, or related field (or equivalent experience).
  • Proven track record in structure-based drug design, ligand pose evaluation, and protein-ligand binding principles.
  • Strong working knowledge of AI/ML-based molecular design platforms and ability to work with predicted protein structures.
  • Experience applying property-based filtering and lead prioritization techniques.

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