Structural Biology Specialist

3 days ago

Vapi, Gujarat, India beBeeStructuralBiologist Full time ₹ 9,00,000 - ₹ 12,00,000
Senior Molecular Biologist Position

We are seeking a highly skilled and motivated Senior Molecular Biologist to join our drug discovery programs. The ideal candidate will bring deep expertise in macromolecular structure determination and modeling, with a focus on elucidating protein structures, analyzing ligand binding, and driving rational drug design in collaboration with computational and medicinal chemistry teams.


Key Responsibilities:
  • Analyze protein-ligand interactions to inform medicinal chemistry and lead optimization efforts.
  • Conduct molecular dynamics (MD) simulations and free energy calculations to evaluate complex stability and binding energetics.
  • Apply structural insights to guide hit-to-lead and lead optimization strategies.
  • (Preferred) Utilize machine learning models to support binding site prediction or compound prioritization

Required Skills & Qualifications:
  • Strong expertise in structural biology techniques, such as crystallography, cryo-EM, or NMR are desirable.
  • Proficient in macromolecular modeling and structure refinement tools (e.g., Phenix, Coot, Chimera, PyMOL).
  • Experience with protein-ligand docking, structure validation, and interaction mapping.
  • Hands-on experience with molecular dynamics simulations using tools such as GROMACS, AMBER, NAMD, or CHARMM.
  • Familiarity with structure-based drug design platforms (e.g., Schrödinger, AutoDock).
  • Scripting or programming experience (Python, R, Bash) for workflow automation and structural data analysis

Benefits:
  • Work on high-impact, discovery-stage therapeutic programs.
  • Collaborative and interdisciplinary research environment.
  • Access to state-of-the-art computational and structural biology platforms.

What We Offer:

We offer a competitive salary and benefits package, as well as opportunities for professional growth and development. Our team is committed to fostering a culture of innovation, teamwork, and excellence.

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