Manager / Sr. Manager - Downstream Processing, R&D

3 days ago


Delhi India Panacea Biotec Full time

Job Description Best fit profile - Knowledge in handling and troubleshooting purification methods at small scale and pilot scale - Various Chromatography techniques like Ion exchange, Affinity, HIC etc. - Ultrafiltration TFF (Hollow Fiber/Cassettes). - Should be well versed with FPLC, AKTA- Process, AKTA- Pilot. Responsibilities - Purification method development, optimization, & execution for bacterial & viral vaccines. - Experience in Cell lysis, different chromatography platform, TFF system, Filtration unit and other unit operations used in protein purification. - Purification method optimization and development for protein expressing in E.coli and mammalian cell culture. - Execution of In House Calibration of AKTA System, spectrophotometer, Auto pipettes, Weighing balance and supervision of In House Calibration of pH /conductivity meter. - Execution of scale up & scale down experiment for purification of Vaccines and biologics to obtain high yield & quality product. - Downstream Process development, optimization & scale up of different vaccine bulk (Dengue Vaccine, Hepatitis A Vaccine and E.coli, BPBC /CEPI Vaccine). - Co-ordination with technology transfer of production process and prioritization of tasks and completion of those in a timely manner. - Any other responsibilities as assigned by R&D Head. - Literature, research paper review and its implementation of new ideas. - Preparation of process development report, process consistency report as per timelines. - Preparation of SOPs, BPRs, protocol report and other documents required for R &D related activities - IQ, OQ and PQ of new equipment's to be installed in downstream processing area. Qualifications - PhD/M.SC in Biotechnology. - Having experience in Down Stream process (Protein Purification). - Preferably from R&D setup. Experience Post PhD - 8+ Years of experience Post master's - 16+ Years of experience



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