(15h Left) Associate Scientific Director, Translational Quantitative Pharmacology

Work Your Magic with us Ready to explore break barriers and discover more We know you ve got big plans - so do we Our colleagues across the globe love innovating with science and technology to enrich people s lives with our solutions in Healthcare Life Science and Electronics Together we dream big and are passionate about caring for our rich mix of people customers patients and planet That s why we are always looking for curious minds that see themselves imagining the unimaginable with us United As One for Patients our purpose in Healthcare is to help create improve and prolong lives We develop medicines intelligent devices and innovative technologies in therapeutic areas such as Oncology Neurology and Fertility Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life Joining our Healthcare team is becoming part of a diverse inclusive and flexible working culture presenting great opportunities for personal development and career advancement across the globe PURPOSE OF THE ROLE The Associate Scientific Director Translational Quantitative Pharmacology TQP position in Quantitative Pharmacology QP within the broader Clinical Measurement Sciences CMS organization is a scientific and cross-functional role responsible for developing and executing Model Informed Drug Development MIDD strategies across the R D lifecycle This position will be responsible for all TQP assignments either executed internally or in collaboration with external TQP related CROs by providing close scientific and technical supervision The incumbent will be expected to manage multiple projects simultaneously and participate in discussions and presentations The role requires the candidate toalso communicate TQP related science and strategies to all interfacing disciplines at the project or non-project levelsand help develop modeling toolboxes to assist project teams in making quantitatively-driven decisions SPECIFIC JOB DESCRIPTION KEY ACCOUNTABILITIES To be an independent contributor in the field of translational quantitative pharmacology to help advance the fundamental science of the field to help guide educate mentor and contribute to the success of the discipline within the company To be able to independently develop quantitative mechanism-based PK PD models that will inform compound progression decisions from lead optimization to clinical proof of concept and beyond for the immunology and oncology pipelines for all modalities of interest The incumbent will have responsibilities for performing human PK predictions and quantitative DDI predictions the design and analysis of pre-clinical PK PD experiments and data to support preclinical development and translational PK PD analyses to support FIM dose estimates for all modalities of interest The incumbent will work to develop models or use commercially available software tools to understand and quantify toxicological signals such as cardiovascular hepatic renal dermal etc to determine the therapeutic index and help guide project decisions To be able to interact with various project team members in a clear and timely manner understanding the functions of other team members and being able to explain and educate model-based analyses and results to team members from various backgrounds The incumbent candidate will work in a dynamic team with frequent interactions both within the team and with associated functions and will be responsible for the development and implementation of innovative modeling and simulation platforms strategy that ensure that the right drug is administered to the right patient at the right dosage As a member of project teams and sub-teams the incumbent will represent QP and present analysis outcomes to cross-functional teams at department meetings project review committees and conferences The candidate will contribute to the preparation and presentation of both internal and external documentation e g Investigator s Brochure IND CTD and program strategy STRATEGIC IMPACT Provide technical expertise to promote and deliver on MIDD strategy of the QP organization COOPERATION Interfaces with other Departments Functions Oncology and Neurology Immunology Research Units Clinical Pharmacology CP Biostatistics Safety Sciences Toxicology DMPK Biomarkers Pharmacometrics Data Sciences Project Teams External Interfaces Represent company organization in consortia e g IQ working groups and academic research partnerships Represent function and department in interactions with contractors Present and publish work in relevant journals and MIDD related conferences CANDIDATE S PROFILE Qualifications Experience Knowledge Competencies EDUCATION LANGUAGES A minimum of 5 years in industry and or academia in a relevant background A PhD in Pharmacokinetics Pharmaceutical Sciences Biomedical Chemical Engineering Applied Mathematics or a related discipline with a proven track record of applying modeling and simulation approaches to biological problems Fluency in English PROFESSIONAL SKILLS EXPERIENCE Sound knowledge of the theory and principles of Quantitative Systems Pharmacology plus hands-on competence in mathematical modeling of pharmacologic effects with mechanism-based models using relevant software or programming languages e g MATLAB SimBiology NONMEM R Monolix Experience in applying translational PK PD M S including QSP approaches in research and early clinical development to inform confidence in target mechanism dose regimen and combinations Knowledge of basic principles of biology and pharmacology at the organismal cellular and molecular level preferably in one or more of the following areas oncology immuno-oncology immunology Ability to rapidly assimilate knowledge of complex biology of drug action for novel mechanisms and transform such understanding into multi-scale mathematical models with requisite mathematical and computational proficiency Experience in applying PBPK modeling and simulation using relevant software e g MATLAB Simcyp GastroPlus is desirable Experience with toxicological predictions using tools such as DILI Sym RenaSym for hepatic and renal toxicity respectively is highly desirable Ability to mentor educate and explain modeling concepts and approaches to colleagues within QP CMS and the larger organization as well Flexibility and keen pursuit of innovation throughout all phases of the drug discovery and development process A desire to develop and grow by way of taking responsibility and engaging in additional tasks and operations Ability to work independently and deliver results in a timely manner Publications in conference proceedings and peer-reviewed journals is desirable Excellent communication skills with the ability to translate and summarize outcomes of modeling and simulation analysis as relevant for research and development projects What we offer We are curious minds that come from a broad range of backgrounds perspectives and life experiences We believe that this variety drives excellence and innovation strengthening our ability to lead in science and technology We are committed to creating access and opportunities for all to develop and grow at your own pace Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity