Senior Scientist, Systems Medicine

Job Title: Senior Scientist, Systems Medicine Global Career Level: D Introduction to role: Are you ready to dive into the world of Systems Medicine and make a significant impact on drug development? As a Senior Scientist, you'll be at the forefront of scientific innovation, utilizing systems modeling techniques to drive decisions in drug discovery and development. Your expertise will be pivotal in developing advanced models that facilitate groundbreaking progress in treating complex diseases. Accountabilities: - Create, expand, or refine mathematical models to address drug-discovery and development questions.- Review, analyze, and prepare available data for modeling purposes and apply best modeling approaches to enhance project decision-making.- Develop/apply PKPD/TKTD models to enable translation of findings from preclinical species to humans.- Develop and utilize mathematical models to enhance quantitative understanding of mechanisms based on literature and in-house data, including identifying relevant data for model development, optimization, and validation.- Influence experimental design by using available data and appropriate modeling solutions.- Engage with project teams and present modeling work.- Contribute to the development and implementation of new modeling and simulation strategies for clinical drug development decisions.- Stay up-to-date with emerging literature in modeling and simulation sciences. Essential Skills/Experience: - PhD or similar degree in pharmacometrics, chemical, mechanical or biomedical engineering, physics, applied mathematics or related field.- Excellent understanding of theory, principles and statistical aspects of mathematical modeling and simulation, including numerical methods, parametrization and ODEs.- Hand-on knowledge of modeling with ODEs and statistical modelling.- Experience with modeling and data analysis tools and languages such as R or Matlab or Python.- Self-directed, independent and highly-motivated researcher who excels in a collaborative, multi-disciplinary environment.- Ability to interact across pre-clinical and clinical teams.- Excellent oral and written communication skills and the ability to interact effectively with scientists in other subject areas with a positive and collaborative attitude.- Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop models.- Ability to keep up to date with and propose the implementation of scientific and technological developments.- Minimum 3 published papers. Desirable Skills/Experience: - Industry or postdoctoral experience in building, validating and using predictive mathematical models (PKPD/TKTD/mechanistic models).- Exposure to current principles and concepts in DMPK, Toxicology and Safety.- Experience with PK, PKPD, TKTD modelling and joint longitudinal modelling tools such as Monolix or any other relevant software’s.- Knowledge of models of biological pathways/systems to support translational research.- Familiarity with the challenges of drug discovery and forward thinking with respect to the general application of mathematical models in discovery and development.- Evidence of identifying, developing, and applying innovative solutions to scientific and technological problems faced in systems and predictive modelling.- Scientific leadership as evidenced by publication record. Key Relationships to reach solutions  : Internal (to AZ or team)  Clinical Pharmacometricians Clinical Pharmacologists Statisticians DMPK M&S experts Study, project and safetyPhysicians Translational Scientists Toxicologists External (to AZ)  Credibility with academic partners, investigators, CROs When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. At AstraZeneca, curiosity drives us to explore new scientific frontiers. We are committed to making a difference by fusing data and technology with scientific innovation. Our inclusive environment encourages collaboration across academia, biotech, and industry, empowering us to tackle some of the world's most complex diseases. With a focus on lifelong learning, we offer diverse opportunities for career growth while impacting patients' lives globally. Ready to make an impact? Apply now to join our team of innovators Date Posted 20-Nov-2025Closing Date 19-Dec-2025