Senior Associate Scientist

JOB DESCRIPTION Designation Associate Scientist Senior Associate Scientist Job Location Bangalore Department TM-TDDT About Syngene Incorporated in 1993 Syngene International Ltd is an innovation-focused global discovery development and manufacturing organization providing integrated scientific services to the pharmaceutical biotechnology nutrition animal health consumer goods and specialty chemical industries around the world Syngene s clientele includes world leaders such as Bristol-Myers Squibb Baxter Amgen GSK Merck KGaA and Herbalife Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems improve R D productivity speed up time to market and lower the cost of innovation Job Purpose 1-2 Lines We are seeking motivated master s level scientists MS MTech MSc etc to join the Translational Medicine team at the Biocon Bristol Myers Squibb Research Center in Bangalore India Key responsibilities of this role are to serve as an execution arm for the preclinical support of asset programs through mechanism of action-based studies differentiation from standard of care and competitive therapeutics combination rationale new indications life cycle management and patient selection strategies S He will work directly with translational scientists disease leaders within translational medicine and will also interact with thematic research centers in early development within the company Key Responsibilities Conduct preclinical laboratory experiments on late stage BMS portfolio compounds to support annual goals and objectives for Translational Medicine for internal external collaborations compound specific plans etc Responsible for delivering data in support of translational strategies including biomarkers patient selection hypotheses dose and schedule combination strategies resistance mechanisms and differentiation Interfaces with TM scientists across departments to ensure seamless flow of information for assets which are entering the remit of translational medicine Assists in designing experiments and delivering data for collaborative projects along with TM scientists Maintains comprehensive records communicates regularly and makes presentations within the department as required Reports experimental finding in written nonclinical pharmacology study reports to support regulatory filings Educational Qualification Masters with at least 2 years of relevant work experience across immunology oncology heme-oncology focus areas Industry experience is a plus Multiple positions can range upto 6 years of experience Technical functional Skills Cell culture primary cell isolation cell transfection and single cell cloning including siRNA CRISPR TALEN or HDR workflows Gene expression methods including qRT-PCR and or familiarity with RNA sequencing epigenomic methods including methylation analysis ChIP etc Protein analyses and immunoassays and cell phenotyping analysis e g ELISA MSD Luminex TSA CBA flow cytometry Design setup and execution of autoimmune solid tumor oncology or heme-oncology in vivo pharmacology models Excellent verbal and written communication skills familiarity with standard or relevant software platforms and scientific qualities are expected Competence in analysis and solving of problems keeping track of overall goals Maintain a good understanding of the methodological basis and biological significance of assays performed Forecast potential issues regarding support of assays for current and long-term projects Devise strategic solutions to identified and potential hurdles issues and efficiently and proactively troubleshoot technical and experimental problems Experience 2-6 years Behavioral Skills A self-starter who is can become technically proficient in a diverse set of techniques and assays with a focus on quality and speed and will meticulously follow internal SOPs Good basic lab skills required pipetting balances etc Highly detailed and meticulous high standards of data entering and QC Must be highly adaptive to changing timelines and goals Must be comfortable taking on complex tasks with minimal direct supervision An excellent multitasker with an ability to be level-headed in a fast-paced lab setting Team-oriented and comfortable working in a highly dynamic matrix environment across multiple locations Prior experience working with patient samples i e FFPE tissue Fresh Frozen tissue blood or working in a CLIA GCLP clinical environment is a plus Must be comfortable and able to work with animal rodent or human derived samples Equal Opportunity Employer It is the policy of Syngene to provide equal employment opportunity EEO to all persons regardless of age color national origin citizenship status physical or mental disability race religion creed gender sex sexual orientation gender identity and or expression genetic information marital status status with regard to public assistance veteran status or any other characteristic protected by applicable legislation or local law In addition Syngene will provide reasonable accommodations for qualified individuals with disabilities