Head Pharmacology

Position Purpose The role shall be responsible for leading the in vitro and in vivo ADME (Absorption, Distribution, Metabolism, and Excretion) studies, ensuring high-quality data generation to support drug discovery and development programs. mechanistic ADME studies. Strategic Responsibilities Develop and implement a DMPK strategy aligned with the organization’s drug discovery and development objectives. Establish and grow in vitro and in vivo DMPK capabilities through talent, infrastructure development, and process optimization. Collaborate with cross-functional Internal and external stakeholders. Act as a Subject Matter Expert (SME) in identifying and resolving technical challenges in ADME and PK studies related to solubility, permeability, metabolism, and liability assessment. Foster external collaborations with academia, consortia, and industry partners to stay updated on emerging trends and scientific advancements in DMPK. Operational Responsibilities Lead the design, execution, and interpretation of in vitro and in vivo ADME studies, ensuring data integrity and adherence to regulatory guidelines. Guide junior and peer scientists in best practices for DMPK studies, mechanistic ADME approaches, and multi-property optimization. Oversee and troubleshoot technical aspects of studies related to Metabolite Identification (Met ID), metabolic stability, CYP and hERG liability, solubility, and permeability . Ensure timely and accurate delivery of data packages for study design, compound selection, and regulatory submissions. Utilize PBPK (Physiologically Based Pharmacokinetic) modelling and simulation to predict human PK and optimize clinical translation strategies. Maintain and expand knowledge of analytical tools and technologies for data interpretation, ensuring integration of in vitro, in vivo, and in silico ADME insights. Financial Responsibilities Develop and manage the DMPK department budget , optimizing resources for experimental and operational efficiency. Ensure cost-effective allocation of funds for DMPK studies, technology upgrades, and external collaborations . Support business development by showcasing DMPK capabilities to potential partners, clients, and regulatory agencies. People Responsibilities Drive a culture of scientific excellence, innovation, and collaboration within the team. Provide training and development programs to enhance technical expertise and leadership capabilities of scientists in ADME/DMPK. Foster effective communication within R&D and external stakeholders, ensuring knowledge sharing and cross-functional alignment Education Qualification Education: Ph.D. in Pharmaceutical Sciences, Pharmacokinetics, Biochemistry, Drug Metabolism, or a related field Work Experience Experience: 12-15 years in the pharmaceutical or preclinical CRO industry with expertise in DMPK. Industry to be Hired from Preferably CRO/CDMO or Pharmaceutical & biotechnology industry. Functional Competencies Expertise in in vitro and in vivo PK (Pharmacokinetics) methodologies. Strong understanding of drug metabolism and ADME principles. Proficiency in interpreting PK/PD (Pharmacokinetics/Pharmacodynamics) relationships. Experience in PBPK modeling, metabolite identification, and mechanistic ADME. Knowledge of analytical tools and regulatory requirements for drug discovery and preclinical studies. Interaction Complexity and Team Work Interaction Complexity & Teamwork Interaction Frequency Purpose of Interaction Internal: Project Managers. Research Scientists. Business Development Teams. Executive Leadership. Daily/ Weekly For managing the R&D activities related to drug discovery, Oversee the progress of new projects. External: Pharmaceutical and Biotechnology Companies. Contract Research Organizations. External Laboratories. Government Agencies. As per business needs Fostering collaboration with other entities.