Scientist -Process Purification Downstream

4 weeks ago

New Delhi, India Enzene Biosciences Ltd Full time

Position Summary:We are looking for a highly motivated Scientist – Downstream Purification to lead and execute multiple downstream development projects with moderate supervision. The role reports to the Sr. Principal Scientist and includes managing a team of up to two members. The Scientist will serve as a subject matter expert, drive project execution, support cross-functional interactions, and mentor junior team members to ensure timely and high-quality project delivery.Key Responsibilities- Plan and execute downstream process activities for mammalian and/or microbial recombinant proteins in alignment with project timelines. - Lead ground-level experimental planning, execution, data capture, compilation, and interpretation with the reporting manager. - Review and guide preparation of technical presentations and project documentation. - Represent the department in internal and external project meetings. - Draft and review development reports, BPRs, SOPs, EOPs, and IOPs. - Support prioritization discussions and provide feasibility inputs for new projects. - Troubleshoot technical challenges and collaborate with manufacturing teams for issue resolution. - Oversee laboratory operations including equipment upkeep, cleanliness, and compliance. - Coordinate with cross-functional teams, vendors, and clients for technical discussions. - Ensure adherence to all EHS guidelines for a safe working environment.Required Skills & Experience- Minimum 8 years of hands-on experience in downstream process development for therapeutic proteins or antibodies. - Strong expertise in chromatography, depth filtration, centrifugation, UF/DF, and sterile filtration. - Experience with QbD-based development, DoE studies, and data analytics tools (preferred). - Exposure to scale-up/scale-down studies, technology transfer, and virus clearance studies. - Ability to lead small teams and independently analyze, interpret, and present experimental data. - Familiarity with protein analytical techniques (protein assays, SDS-PAGE, HPLC, etc.) is an added advantage. - Strong technical acumen, problem-solving mindset, and the ability to work in a dynamic, timeline-driven environment. - Excellent planning, communication, organizational, and documentation skills.Education: M.Tech / M.Sc (Full Time )

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