Scientist -Process Purification Downstream

1 week ago


Pune Division, India Enzene Biosciences Ltd Full time

Position Summary: We are looking for a highly motivated Scientist – Downstream Purification to lead and execute multiple downstream development projects with moderate supervision. The role reports to the Sr. Principal Scientist and includes managing a team of up to two members. The Scientist will serve as a subject matter expert , drive project execution, support cross-functional interactions, and mentor junior team members to ensure timely and high-quality project delivery. Key Responsibilities Plan and execute downstream process activities for mammalian and/or microbial recombinant proteins in alignment with project timelines. Lead ground-level experimental planning, execution, data capture, compilation, and interpretation with the reporting manager. Review and guide preparation of technical presentations and project documentation. Represent the department in internal and external project meetings. Draft and review development reports, BPRs, SOPs, EOPs, and IOPs. Support prioritization discussions and provide feasibility inputs for new projects. Troubleshoot technical challenges and collaborate with manufacturing teams for issue resolution. Oversee laboratory operations including equipment upkeep, cleanliness, and compliance. Coordinate with cross-functional teams, vendors, and clients for technical discussions. Ensure adherence to all EHS guidelines for a safe working environment. Required Skills & Experience Minimum 8 years of hands-on experience in downstream process development for therapeutic proteins or antibodies. Strong expertise in chromatography, depth filtration, centrifugation, UF/DF, and sterile filtration. Experience with QbD-based development, DoE studies, and data analytics tools (preferred). Exposure to scale-up/scale-down studies, technology transfer, and virus clearance studies. Ability to lead small teams and independently analyze, interpret, and present experimental data. Familiarity with protein analytical techniques (protein assays, SDS-PAGE, HPLC, etc.) is an added advantage. Strong technical acumen, problem-solving mindset, and the ability to work in a dynamic, timeline-driven environment. Excellent planning, communication, organizational, and documentation skills. Education: M.Tech / M.Sc (Full Time )



  • pune district, India Enzene Biosciences Ltd Full time

    Position Summary: We are looking for a highly motivated Scientist – Downstream Purification to lead and execute multiple downstream development projects with moderate supervision. The role reports to the Sr. Principal Scientist and includes managing a team of up to two members. The Scientist will serve as a subject matter expert , drive project execution,...


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