Scientist - DMPK
4 weeks ago
Desired Profile:
- M. Pharm (Pharmacology / Pharmaceutical Analysis) / M.Sc. (Biochemistry / Pharmaceutical Chemistry) with 11-14 years or Ph.D. with 2-5 years' experience in large molecule/ADC PK and bioanalysis, Antibody Drug Conjugate characterisation and bioanalysis, mass spectrometry-HRMS, Q-TOF & Triple quad
Roles & Responsibilities:
- Expert in designing and executing DMPK studies to support antibody-drug conjugate (ADC) and monoclonal antibody (mAb) programs, from discovery through IND-enabling stages.
- Extensive experience in quantification of biologics including antibodies, therapeutic proteins, ADCs, and peptides using LC-MS/MS, MSD, and ELISA platforms.
- Proficient in advanced bioinformatics tools such as BioPharma Finder, MaxQuant, Spectronaut, and other relevant analytical software.
- Skilled in applying innovative techniques for function-based identification and selection of ADC and mAb lead candidates, with a strong focus on DMPK profiling to ensure safe and effective therapeutic development.
- Experienced in interpreting complex DMPK data and providing actionable insights to cross-functional project teams.
- Actively represent DMPK functions in internal and external meetings, fostering collaboration and strategic alignment.
- Collaborate closely with cross-functional departments to address ADC-related challenges and deliver integrated solutions from target validation to IND submission.
- Accountable for authoring and reviewing SOPs, study protocols, reports, and regulatory documentation to support both GLP and non-GLP studies.
- Strong foundational knowledge of DMPK principles, including PK/PD, toxicology, and translational sciences. Demonstrated capabilities in communication, innovation, and team leadership.
- Accountable for authoring and reviewing SOPs, study protocols, reports, and regulatory documentation to support both GLP and non-GLP studies.
- Collaborate closely with cross-functional departments to address ADC-related challenges and deliver integrated solutions from target validation to IND submission.
- Actively represent DMPK functions in internal and external meetings, fostering collaboration and strategic alignment.
- Experienced in interpreting complex DMPK data and providing actionable insights to cross-functional project teams.
- Skilled in applying innovative techniques for function-based identification and selection of ADC and mAb lead candidates, with a strong focus on DMPK profiling to ensure safe and effective therapeutic development.
- Proficient in advanced bioinformatics tools such as BioPharma Finder, MaxQuant, Spectronaut, and other relevant analytical software.
- Extensive experience in quantification of biologics including antibodies, therapeutic proteins, ADCs, and peptides using LC-MS/MS, MSD, and ELISA platforms.
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