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BBRC - Senior Team Leader - Biopharmaceutics

3 months ago

Bengaluru, India Syngene International Limited Full time

Designation: Senior Team Leader / Senior Group Leader

Job Location: Bangalore

Department: Biopharmaceutics, BBRC


About Syngene

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene’ s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.


Job Purpose (1-2 Lines)

To lead a team of scientists for developing preclinical & clinical formulations of new chemical entities (NCEs).


Key Responsibilities: (Maximum 5-8 Points)

1. Provide scientific leadership within Pharmaceutics domain to identify clinically developable drug candidates, which includes:

• Pre-formulation (physicochemical characterization, polymorphism)

2. Lead projects & guide the team on development of different formulation(s), like solution, suspension, tablet, capsule for:

• Pre-clinical studies,

• GLP toxicology studies, &

• Phase I (FIH) & Phase II clinical studies.

3. Good understanding of drug degradation mechanisms and experimental analysis is preferred.

4. Competency in understanding & assessing biopharmaceutics risks towards potential solubility & absorption issues with NCEs, which includes utilization of various in vitro, in silico & in vivo tools.

5. Good understanding of various novel drug delivery systems (NDDS) to improve oral bioavailability of a challenging NCE.

6. Fair understanding of analytical principles to characterize drug product(s).

7. Ability to investigate process-induced solid-state transformation(s) while developing drug product using crystalline, salt or amorphous solid dispersion forms of drug substance.

8. Knowledge of scientific principles and practices of other pharmaceutical development functional areas such as Chemical Process Research, Drug Metabolism and Pharmacokinetics, Drug Safety Evaluation is desired.


Educational Qualification:

Ph.D. (full time) / Post-Doctorate in Pharmaceutics / Industrial Pharmacy / Pharmaceutical Technology or related field(s)


Technical/functional Skills: (Maximum 4-6 Points)

• Pharmaceutics

• Physical Pharmacy

• Dosage Form Design

• Drug Delivery

• Chemical Degradation

• Biopharmaceutics


Experience:

9-17 years of relevant industrial experience


Behavioral Skills:

• Demonstrated ability of leading/managing a group of scientists for project accountabilities.

• Experience of working with matrix teams in a complex, dynamic environment to effectively achieve objectives.

• Excellent written & oral communication skills, and strong interpersonal & team working skills.

• Demonstrate cross-functional / cross-site collaboration towards project deliverables.

• Train, coach & mentor team members for higher standard of deliverables.


Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.