Scientist - In-Vitro ADME (Biology)

1 month ago

Hyderabad, India Intonation Research Laboratories Full time

Job Title: Scientist - In-Vitro -ADME (Hyderabad)

We are currently seeking a Scientist / Sr Scientist in In-Vitro - ADME to work with Job Title: Scientist - In-Vitro -ADME - Intonation Research Laboratories, Hyderabad


We are currently seeking a Scientist in In-Vitro - ADME to work with our agile team in Nacharam, Hyderabad. Please send a resume and cover letter to:

krojanala@intotech.net

About Intonation Research Laboratories Pvt Ltd.

Intonation Research Laboratories is accelerating drug discovery and creating better therapeutics by supporting its clients chemical synthesis, biochemical and cell-based assays, ADME-PK needs. We have assembled a diverse team with extensive experience across drug discovery disciplines. This continuum of complementary skills is essential for driving our scientific vision and needs to support our clients. We are science-inspired, perseverant, synergistic, supportive, intrepid, and inclusive company. If you are inspired to bring better medicines to patients within a collaborative organization, then Intonation could be the right place for you.

Read More About Us: www.intotech.net

Job Responsibilities

Design and conduct in vitro ADME assays

o Plasma, Microsomal, hepatocyte, SGIF stability

o CYP inhibition/induction and phenotypic assays

o Plasma protein binding, RBS partitioning and tissue distribution

o PAMPA and Caco-2 permeability assays.

o Kinetic and thermodynamic solubility studies

o Experience in maintaining cell culture and cell banking is preferred

In Vitro Sample processing and analysis

o Processing of in vitro assay samples by protein precipitation, solid phase extraction and their analysis of on LCMS/MS

o Bioanalytical method development and validation for quantification of small

molecules (NCEs/drugs/metabolites) and generic molecules as well in different biological matrices (Blood, plasma)

  • Collaborate with team and project team members in Troubleshooting, development and

validation of new ADME cell-based assays and technologies

  • Critically analyze data, interpret and communicate accurate reports, results, and ideas to team members in verbal, written, and presentation formats.

Key Qualifications

Post Graduation in Pharmacology / Biotechnology / Ph.D. with a minimum of 5 years of industrial experience in CRO space

Solid understanding of In-Vitro pharmacology

  • Demonstrated working experience in routine assays including but not limited to solubility assays, Hepatocyte stability assays, Plasma protein binding, permeability assays to GIF assays, and CYP inhibition Assays to demonstrate the metabolic stability enzymes
  • Handling multiple projects with result driven approach.
  • Update with scientific literature advances, developments, and regulatory guidelines in the area of drug metabolism science
  • Knowledge of PK analysis using WinNonlin will be beneficial but not essential.


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