Oligonucleotide Scientist

Key Responsibilities

• Perform solid-phase oligonucleotide synthesis (SPOS) and solid-phase peptide synthesis (SPPS) using automated synthesizers.
• Develop and optimize synthetic routes for various types of oligonucleotide therapeutics, including ASOs, siRNA, aptamers, modified nucleotides, and conjugated oligos.
• Execute purification of oligonucleotides using HPLC, ion-exchange chromatography, desalting, ultrafiltration, and related techniques.
• Conduct analytical characterization using HPLC, LC-MS, UV/Vis, CE, and other relevant instruments.
• Support scale-up activities and tech transfer to manufacturing or pilot-scale facilities.
• Ensure documentation according to regulatory guidelines and maintain compliance with GMP/GLP practices.
• Collaborate with cross-functional teams in development, quality, regulatory, and manufacturing.
• Identify potential issues early and troubleshoot synthesis, purification, or analytical challenges.
• Prepare technical reports, development summaries, batch records, SOPs, and regulatory supporting documents.

Required Skills & Qualifications

• Masters or Ph.D. in Organic Chemistry / Medicinal Chemistry / Biotechnology / Pharmaceutical Sciences or related discipline.
• Strong foundation in organic chemistry, particularly in nucleotide and peptide chemistry.
• Hands-on experience in solid-phase synthesis of oligonucleotides and peptides.

• Deep understanding of:

• Oligonucleotide drug classes and modifications (e.g., phosphorothioates, 2'-modifications, LNA, GalNAc conjugates).

• Chemistry of synthesis, purification, and analytical characterization.

• Drug development lifecycle, regulatory expectations, and CMC requirements.

• Ability to anticipate issues, evaluate root causes, and provide effective technical solutions.

• Strong communication, interpersonal, and technical writing/documentation skills.

Preferred Experience

• Experience with automated synthesizers (e.g., MerMade, AKTA, OligoPilot).
• Exposure to process development, scale-up, or manufacturing of oligonucleotides.
• Familiarity with regulatory submissions (Module 3/Chemistry & Manufacturing) is a plus.