Principal Investigator-Scientific Ladder

Date: 9 Jun 2025

Location:

Kolthur Shamirpet, Medchal, TG, IN, 500078

Custom Field 1: Discovery Services

Job Role: Principal Investigator-Scientific Ladder – Medicinal Chemistry
Department – Discovery Chemistry
Job location: Hyderabad
At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit
Mandatory expectation for all roles as per Syngene safety guidelines:

• Overall adherence to safe practices and procedures of oneself and the teams aligned
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company's integrity & quality standards
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self
• Compliance to Syngene' s quality standards at all times
• Hold self and their teams accountable for the achievement of safety goals
• Govern and Review safety metrics from time to time

Job Purpose

• Provide strategic and scientific leadership to integrated drug discovery projects for our clients
• Liaise with the Functional Head - Medicinal Chemistry on projects priorities and ensure that project deliverables are met.
• As program leader supervise one/ two medicinal chemistry project(s).
• Analyze SAR and design new set of compounds using Comp Chem tools to address various MedChem issues.
• Provide regular updates on project progress to the Section Head - medicinal chemistry / Functional Leads and clients.
• Work collaboratively with the CADD scientists, biologists, DMPK scientists and the safety pharmacologists.
• Exceptional creativity and innovation in the genuine spirit of collaboration
• Core commitment to safety, integrity, compliance, quality, and service

Key Responsibilities

• Candidate should have a minimum of yrs. experience in drug discovery from pharmaceutical or biotech industry.
• Excellent understanding of the concepts of drug discovery, preferably having prior experience of progressing a project from hit identification to lead optimization.
• Has prior experience working with a cross-functional team, comprising assay biologists, Structural biologists, DMPK scientists, computational chemists, and safety pharmacologists.
• Familiarity with molecular modelling concepts and tools is desirable.
• Strong knowledge of data analysis (SAR/SPR) and informatics tools.
• Familiarity with cGMP and regulatory knowledge.
• Strong Client communication and presentation skills.
• Extensive knowledge and experience in synthesis planning, synthetic methods and use of modern chromatographic and analytical tools.
• Proven ability to lead and motivate the teams.
• Excellent written and verbal communication skills.
• A team player / works well in multi-discipline teams
• Builds strong plans to provide clarity for others, and utilizes time management tools and capabilities

Educational Qualification

• Ph.D./PDF in Organic /Medicinal Chemistry or relevant field.

Technical / Functional Skills

• Possess a very high scientific capability.
• Knowledge of route scouting.
• Sound knowledge of Process safety and hazard evaluation.
• Excellent cGMP and regulatory knowledge.
• Strong knowledge of Data analysis software.
• Strong Client communication skills.
• Cross-departmental interaction.

Experience:
Minimum 6-9 years of experience for Ph.D / Post Doc

Behavioral Skills

• Sound interpersonal skills.
• Good Team skills
• Time Management skills
• Strong system thinking and trouble shooting ability.
• Sound leadership

Equal Opportunity Employer
It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities