Staff Software Engineer

What if the work you did every day could impact the lives of people you know? Or all of humanity?At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients.Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world changing projects, you will do more and become more than you ever thought possible.

We are looking for an experienced Staff Software Engineer to drive the design and delivery of scalable, secure, and business-aligned solutions across our cloud ecosystem. This role bridges business strategy and technology execution, requiring deep technical proficiency across multiple technologies.

You will work closely with stakeholders to understand business needs and translate them into effective architectural solutions. As a key technical leader, you will guide engineering teams, shape system architecture, and ensure our technology investments support long-term business success.

Responsibilities:

• Lead the design and architecture of cloud-native solutions that align with business objectives and user needs.
• Partner with business units, product managers, UX teams, and engineering to define end-to-end solutions that balance functionality, scalability, performance, and cost-effectiveness.
• Act as the architectural owner across application layers—UI, backend services, APIs, databases, and cloud infrastructure.
• Guide the integration of AI/ML, data engineering, and operational workflows into cohesive business solutions.
• Exposure to or knowledge of BI tools like Power BI and/or Tableau.
• Produce clear architectural documentation, solution proposals, and system blueprints to drive implementation.
• Uphold enterprise standards for security, performance, and maintainability.
• Provide leadership during system troubleshooting and contribute to incident resolution with a holistic architectural perspective.
• Support strategic planning, technical roadmaps, and continuous improvement initiatives in line with business growth.

Preferred Experience/Education/Skills:

• Bachelor's or master's degree in computer science, Engineering, or related discipline.
• 8+ years in project lifecycle, with at least 3 years focused on architecture or technical design.
• Framework & development experience - Strong technical foundation in     / Express / NestJS (JavaScript / TypeScript), Angular and modern full stack experience. .NET (C#) is an added advantage.
• CI/CD / DevOps - Exposure to GitHub Actions/Team City,/Jenkins.
• Cloud platform & Infrastructure - Experience on Cloud platform Infrastructure (AWS/Azure) and Container orchestration (Dockers and/or Kubernetes)
• Observability - Exposure to / knowledge of Performance monitoring tools like Splunk or Grafana
• Performance Tuning & Optimisation – Exposure to Optimising system performance, ability to diagnose and address bottlenecks and be able to troubleshoot complex systems.
• Familiarity with data architecture, quality, and governance best practices.
• Business alignment and stakeholder communication - Ability to translate business needs into technical solutions and communicate effectively with stakeholders.
• Leadership and Mentorship – Effectiveness in guiding teams, promoting best practices, mentoring developers and leading continuous improvement activities.
• Relevant certifications (e.g., Azure Solutions Architect Expert, AWS) are a plus.

Position Summary:

Plans, designs, develops and tests software systems or applications for software enhancements and new products including cloud-based or internet-related tools.

Changes to individual responsibilities may occur due to business needs and other related duties may be assigned.

Scope of Responsibilities:

• Applies advanced wide-ranging experience and professional knowledge to provide solutions in creative and effective ways.
• Directs the application of existing principles and guides development of new policies and ideas. Understands the interrelationships of different disciplines.
• Works on complex assignments where problem solving requires in-depth evaluation of varying factors and practices/procedures must be determined.
• Enhances internal and external working relationships and networks with key contacts outside area of expertise.
• Adapts style to differing audiences and frequently advises others on complex matters that relate to the wider business and require persuasion.
• May train and mentor junior team members and peers alike.
• Work is reviewed upon completion and is consistent with team / departmental objectives.
• Exercises judgment in selecting methods, techniques, and evaluation criteria for obtaining results.

Experience/Education:

• Typically requires a minimum of 8 years of related experience with a Bachelor's degree/ Advanced degree

We are a company deeply rooted in belonging, promoting an inclusive environment where employees feel valued and empowered to contribute to our mission. Built on a strong foundation, Illumina has always prioritized openness, collaboration, and seeking alternative perspectives to propel innovation in genomics. We are proud to confirm a zero-net gap in pay, regardless of gender, ethnicity, or race. We also have several Employee Resource Groups (ERG) that deliver career development experiences, increase cultural awareness, and offer opportunities to engage in social responsibility. We are proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information. Illumina conducts background checks on applicants for whom a conditional offer of employment has been made. Qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable local, state, and federal laws. Background check results may potentially result in the withdrawal of a conditional offer of employment. The background check process and any decisions made as a result shall be made in accordance with all applicable local, state, and federal laws. Illumina prohibits the use of generative artificial intelligence (AI) in the application and interview process. If you require accommodation to complete the application or interview process, please contact To learn more, visit: The position will be posted until a final candidate is selected or the requisition has a sufficient number of qualified applicants. This role is not eligible for visa sponsorship.

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