Principle Scientist, Translational Quantitative

Work Your Magic with us

Ready to explore, break barriers, and discover more? We know you've got big plans - so do we Our colleagues across the globe love innovating with science and technology to enrich people's lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

**Your role**:

- To be able to independently develop quantitative mechanism-based PK/PD models that will inform compound progression decisions from lead optimization to clinical proof of concept and beyond for the immunology and oncology pipelines, both for large and small molecule pharmaceuticals.
- To be able to interact with various project team members in a clear and timely manner, understanding the functions of other team members and being able to explain and educate modeling efforts and results to team members from various backgrounds

Interfaces with other Departments/Functions:

- Oncology and Immunology Research Units
- Clinical Pharmacology (CP)
- Biostatistics
- Safety sciences (Toxicology)
- DMPK
- Epidemiology/Biomarkers
- Pharmacometrics
- Bioinformatics
- Project Teams (CP, Biomarkers and GPT)

External Interfaces:

- Represent company/ organization in consortia (e.g. IQ working groups) and academic research partnerships.
- Represent function and department in interactions with contractors
- Present and publish work in relevant journals and MIDD related conferences.

**Who you are**:
EDUCATION/LANGUAGES
- A minimum of 3 years in industry and/or academia in a relevant background
- Fluency in English.

PROFESSIONAL SKILLS & EXPERIENCE
- In-depth hands-on experience with modeling software (such as; MatLab, R, Phoenix/WinNonlin, NONMEM, Monolix etc)
- Experience with DDI predictions using appropriate static and dynamic approaches (SimCyp) are desirable
- Experience with toxicological predictions using tools such as DILI Sym/RenaSym for hepatic and renal toxicity respectively is highly desirable
- Openness to fresh ideas and new perspectives to be gathered from working with people from diverse backgrounds and cultures.
- Flexibility and keen pursuit of innovation throughout all phases of the drug discovery and development process
- A desire to develop and grow by way of taking responsibility and engaging in additional tasks and operations.
- Ability to work independently and deliver results in a timely manner
- Publications in conference proceedings and peer-reviewed journals are encouraged
- Excellent communication skills with the ability to translate and summarize outcomes of modeling and simulation analysis as relevant for discovery and development projects

Other Requirement:
Normal and routine office duties

Position requires both domestic and international travel up to 20% of time

**What we offer**:We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We celebrate all dimensions of diversity and believe that it drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress