BBRC - Associate Scientist - Lead Discovery & Optimization (LDO)

1 month ago

bangalore, India Syngene International Limited Full time
JOB DESCRIPTION
Designation: Designation: Associate Scientist (8-I)
Job Location: Bangalore
Department: In vitro Pharmacology - Neuroscience, LDO
About Syngene
Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene’ s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.
Job Purpose (1-2 Lines)
BBRC is seeking an experienced scientist (MS/MTech/MPharm) with expertise in Neuroscience to join their Molecular Pharmacology group in their mission of discovery and validation of therapeutic targets and participation in drug discovery programs. Applicants with expertise in neurodegenerative diseases like Alzheimer’s/Multiple Sclerosis etc and other neurological conditions like Schizophrenia are particularly encouraged to apply.
Key Responsibilities:
• Design and conduct rigorous experiments including cell based (cell-lines, primary neurons and human iPSCs) and biochemical assays, aimed at execution of discovery programs focused on neuropsychiatric diseases
• Routinely perform occupancy assays etc to analyze changes in target engagement from cell cultures, brain and peripheral tissues
• Independently determine in-vitro pharmacologic methods and procedures to study modulation of GPCRs/neurotransmitter receptors in the primary neurons/human iPSC neurons etc
• Develop and troubleshoot assays independently, record, analyze and communicate scientific data; ensure the accuracy and reliability of data
• Search and review the scientific literature independently on the target biology
Educational Qualification: MS, MTech or MPharm in enzymology, biochemistry, molecular biology or related discipline
Experience: 5-6 years
Technical/functional Skills:
• Experience in neuropharmacology/small molecule pharmacology at therapeutically relevant GPCRs/neurotransmitter receptors at the molecular level in the CNS
• Demonstrated technical proficiency in biochemical, cellular, and/or radioligand binding assay systems to assess drug target engagement
• Ability to perform ex-vivo receptor occupancy assays in the brain tissues to understand receptor targeted drug efficacies
• Hands-on experience in complex cellular models/ex-vivo systems, including designing and executing mechanistic/pharmacological characterization of lead candidates
• Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature
Behavioral Skills: Strong problem-solving and data analysis skills, excellent written and verbal communication skills, good presentation skills, and the ability to handle multiple projects simultaneously and meet aggressive project timelines. Must demonstrate integrity and take accountability for their work
Equal Opportunity Employer:
It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.

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