Scientist - Peptide Process R &D

14 hours ago

Delhi, India Aurigene Pharmaceutical Services Limited Full time

About the jobJob DescriptionJob Title: Scientist - Peptide Process R &D( Proven track record in both SPPS and LPPS is highly desirable)Education & Experience : M.Sc./PhD Organic chemistry with experience on Peptide Process R &D with 3 to 15 years of experience. .1.0 Position SummaryWe are seeking a highly skilled and motivated Research Scientist specializing in peptide chemistry. The ideal candidate will be responsible for the design, execution, optimization, and scale-up of synthetic peptides using both Solid-Phase Peptide Synthesis (SPPS) and Liquid-Phase Peptide Synthesis (LPPS) methodologies. This role requires hands-on expertise in various synthesis techniques, purification, and analytical characterization, as well as a strong commitment to safety, documentation, and project management within a dynamic R&D environment.2.0 Key ResponsibilitiesA. Peptide Synthesis & DevelopmentDesign and execute multi-step synthesis of complex peptides (up to 30-40 mers) using manual and automated SPPS techniques.Demonstrate expertise with a wide range of peptide synthesis resins (e.g., 2-CTC, Rink Amide, Wang, Sieber) and select appropriate resins, protecting groups (Fmoc/Boc), coupling reagents, and solvents for target sequences.Perform advanced peptide modifications, including disulfide bridging, lactamization, and other cyclization strategies.Conduct peptide synthesis in solution phase (LPPS) utilizing both Fmoc and Boc protection strategies.Expertly carry out critical downstream processes, including resin cleavage, global deprotection, quenching, and product isolation.B. Instrumentation & TechnologyOperate, troubleshoot, and maintain automated peptide synthesizers.Utilize microwave peptide synthesizers (e.g., CEM Liberty Blue) to optimize reaction conditions and improve synthesis efficiency.Conduct synthesis at various scales using manual peptide reactors (1 L to 10 L).C. Purification & AnalysisPurify crude peptides using preparative Reverse-Phase High-Performance Liquid Chromatography (RP−HPLC) and perform subsequent lyophilization.Interpret analytical data (e.g., HPLC, Mass Spectrometry) to assess reaction progress, purity, and yield, and generate trend data to guide process optimization.Conduct comprehensive literature surveys to support the development of novel and efficient synthesis strategies.D. Compliance, Safety & DocumentationMaintain meticulous, real-time documentation of all experiments and results in an Electronic Lab Notebook (eLN).Ensure strict adherence to laboratory safety procedures to prevent incidents and maintain a safe working environment.Provide technical support for the technology

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