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17 hours ago
We are looking for a Principal Scientist to lead our Downstream Process Optimisation & Protein Purification team of 4 scientists and report to the VP of R&D. This is a leadership role at the forefront of biotechnology innovation, with direct impact on taking recombinant proteins from R&D scale to commercial manufacturing.
Oversee budget planning, strategy, and execution for downstream R&D activities.
Implement and validate virus removal/inactivation steps to meet global regulatory standards.
Translate research protocols to commercial-scale processes , collaborating closely with the commercial production team.
Establish and maintain robust R&D processes , ensuring timelines and milestones are met.
Participate in recruitment, training, and development of team members.
Required Skills & Experience
~ PhD or Master’s degree in Biotechnology, Bioprocess Engineering, Biochemistry, or related field.
~7+ years (PhD) or 10+ years (Master’s) of industry experience in Recombinant Protein Purification and Downstream Processing .
~ Proven track record of scaling up purification processes from R&D to commercial manufacturing.
~ Experience in working with complex eukaryotic expression systems – preference for candidates with insect-based expression experience.
~ Exposure to IP processes and working with legal/IP teams.
~ Must Have Hands-On Experience
Chromatography Systems - AKTA or equivalent FPLC/HPLC systems for affinity, ion exchange, hydrophobic interaction, and size exclusion chromatography.
# Tangential Flow Filtration (TFF) / Ultrafiltration Units - Protein concentration, buffer exchange, and diafiltration at R&D and pilot scale.
# Virus Removal & Inactivation Equipment - Depth filtration units, virus filtration modules (e.g., 20 nm filters), and chemical inactivation setups.
Bioreactor Harvest & Clarification Systems - Continuous and batch clarification units suitable for insect biomass processing.
# Clean-In-Place (CIP) & Steam-In-Place (SIP) Systems - For maintaining GMP compliance in purification operations.
# Lead a high-impact team in a fast-growing VC-backed biotech .
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