Senior Biopharmaceutical Scientist

4 days ago

Chennai, Tamil Nadu, India beBeeBiopharmaceutical Full time ₹ 1,80,00,000 - ₹ 2,50,00,000

As a Senior DMPK Scientist, you will play a key role in supporting the development of antibody-drug conjugate (ADC) and monoclonal antibody (mAb) programs. Your expertise in designing and executing DMPK studies will be crucial in ensuring the safe and effective therapeutic development of these programs.

Key Responsibilities:

  • Design and execute DMPK studies to support ADC and mAb programs from discovery through IND-enabling stages.
  • Quantify biologics including antibodies, therapeutic proteins, ADCs, and peptides using LC-MS/MS, MSD, and ELISA platforms.
  • Utilize advanced bioinformatics tools such as BioPharma Finder, MaxQuant, Spectronaut, and other relevant analytical software.
  • Apply innovative techniques for function-based identification and selection of ADC and mAb lead candidates with a strong focus on DMPK profiling.
  • Interpret complex DMPK data and provide actionable insights to cross-functional project teams.
  • Represent DMPK functions in internal and external meetings, fostering collaboration and strategic alignment.
  • Collaborate closely with cross-functional departments to address ADC-related challenges and deliver integrated solutions from target validation to IND submission.
  • Author and review SOPs, study protocols, reports, and regulatory documentation to support both GLP and non-GLP studies.

Requirements:

  • M. Pharm (Pharmacology / Pharmaceutical Analysis) or M.Sc. (Biochemistry / Pharmaceutical Chemistry) degree with 12-15 years' experience or Ph.D. with 5 years' experience.
  • Expertise in PK/PD, toxicology, and translational sciences.
  • Strong communication, innovation, and team leadership skills.
  • Proficient in Excel software.

Competencies:

  • Antibody, ADC characterisation
  • Communication Skills
  • Excel software Skills
  • Interpersonal Skills

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