
Expertise in Oligonucleotide Synthesis
1 day ago
At our cutting-edge research facility, you will spearhead oligonucleotide synthesis and analysis for pioneering therapeutic and diagnostic programs.
Key Responsibilities:
- Optimize and troubleshoot automated solid-phase synthesis (detritylation–oxidation cycles).
- Scale synthesis to mmol level with coupling efficiency exceeding 99%.
- Purify and characterize oligos using HPLC, PAGE, CE, LC-MS, UV-Vis, and MS techniques.
- Maintain lab equipment, inventory, safety protocols, and standard operating procedures.
- Drive cross-functional method development and quality control initiatives.
Qualifications:
- Ph.D. degree in oligonucleotide synthesis and analysis or a related field with 2–5 years of experience.
- Strong foundation in phosphoramidite chemistry, purification, and analytics.
- Bonus: experience with modified or therapeutic oligos, digital PCR/BEAMing techniques.
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