Expertise in Oligonucleotide Synthesis

1 day ago


Kannur, Kerala, India beBeeSynthesis Full time ₹ 20,00,000 - ₹ 25,00,000
Lead Oligo Synthesis Scientist

At our cutting-edge research facility, you will spearhead oligonucleotide synthesis and analysis for pioneering therapeutic and diagnostic programs.

Key Responsibilities:

  • Optimize and troubleshoot automated solid-phase synthesis (detritylation–oxidation cycles).
  • Scale synthesis to mmol level with coupling efficiency exceeding 99%.
  • Purify and characterize oligos using HPLC, PAGE, CE, LC-MS, UV-Vis, and MS techniques.
  • Maintain lab equipment, inventory, safety protocols, and standard operating procedures.
  • Drive cross-functional method development and quality control initiatives.

Qualifications:

  • Ph.D. degree in oligonucleotide synthesis and analysis or a related field with 2–5 years of experience.
  • Strong foundation in phosphoramidite chemistry, purification, and analytics.
  • Bonus: experience with modified or therapeutic oligos, digital PCR/BEAMing techniques.


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