Scientist - R&D Downstream

2 weeks ago


bangalore, India Laurus Bio Full time

Job Title: Scientist Downstream R&DJob Summary:We are looking for a Scientist Downstream R&D to lead the development and optimization of protein purification processes. The role involves chromatography, ultrafiltration, filtration, and process scale-up to ensure efficient and scalable downstream processing. The candidate will collaborate with cross-functional teams to support process development, technology transfer, troubleshooting, and regulatory documentation.Qualifications:Masters in Biotechnology, Biochemistry, or a related field with 8-10 years of industry experience.PhD in Biotechnology, Biochemistry, or a related field with 4- 6 years of industry experience.Roles & Responsibility:Technical Expertise:Extensive experience in protein purification, chromatography (KTA), ultrafiltration, and TFF.Strong understanding of bioprocess engineering, process scale-up, and automation.Soft Skills: Analytical mindset, problem-solving ability, and strong collaboration skills.Preferred: Experience with DOE, statistical analysis, and high-throughput screening is a plus.Key Responsibilities:Protein Purification & Process Development:Develop and optimize chromatography-based purification (affinity, ion exchange, size exclusion), ultrafiltration, and filtration techniques.Design and execute experiments for process characterization, yield improvement, and cost efficiency.Implement high-throughput screening and automation-based purification strategies.Scale-Up & Technology Transfer:Lead process scale-up from laboratory to pilot and manufacturing scales.Support technology transfer, process validation, and regulatory documentation.Process Characterization & Troubleshooting:Investigate process deviations, troubleshoot purification challenges, and implement corrective actions.Enhance process robustness and reproducibility through optimization studies.Regulatory Compliance & Documentation:Maintain detailed experimental records, write technical reports, and contribute to cGMP, ICH, FDA regulatory documentation.Collaboration & Cross-Functional Interaction:Work closely with Upstream, Analytical, and Formulation teams to ensure smooth process integration.Participate in cross-functional discussions to drive efficiency and innovation.Process Optimization & Innovation:Apply Design of Experiments (DOE) and statistical analysis for process development.Explore new purification strategies, automation, and continuous processing techniques.


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