Senior Scientist- DMPK
3 weeks ago
Desired Profile: M. Pharm (Pharmacology / Pharmaceutical Analysis) / M.Sc. (Biochemistry / Pharmaceutical Chemistry) with 12-15 years or Ph.D. with 5 years’ experience
Job Description, Key Skills and Competencies:
- Expert in designing and executing DMPK studies to support antibody-drug conjugate (ADC) and monoclonal antibody (mAb) programs, from discovery through IND-enabling stages.
- Extensive experience in quantification of biologics including antibodies, therapeutic proteins, ADCs, and peptides using LC-MS/MS, MSD, and ELISA platforms.
- Proficient in advanced bioinformatics tools such as BioPharma Finder, MaxQuant, Spectronaut, and other relevant analytical software.
- Skilled in applying innovative techniques for function-based identification and selection of ADC and mAb lead candidates, with a strong focus on DMPK profiling to ensure safe and effective therapeutic development.
- Experienced in interpreting complex DMPK data and providing actionable insights to cross-functional project teams.
- Actively represent DMPK functions in internal and external meetings, fostering collaboration and strategic alignment.
- Collaborate closely with cross-functional departments to address ADC-related challenges and deliver integrated solutions from target validation to IND submission.
- Accountable for authoring and reviewing SOPs, study protocols, reports, and regulatory documentation to support both GLP and non-GLP studies.
- Strong foundational knowledge of DMPK principles, including PK/PD, toxicology, and translational sciences. Demonstrated capabilities in communication, innovation, and team leadership.
Competencies:
- Antibody, ADC characterisation
- Communication Skills
- Excel software Skills
- Interpersonal Skills
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Bengaluru, India Aurigene Oncology Limited Full timeDesired Profile: M. Pharm (Pharmacology / Pharmaceutical Analysis) / M.Sc. (Biochemistry / Pharmaceutical Chemistry / Analytical Chemistry) with 5-8 years or Ph.D. with 2-5 years’ experience. Job Description, Key Skills and Competencies: Experience in designing, performing, and interpreting metabolite identification studies- Invitro and Invivo. ...
