BBRC - Research Investigator - Neuroscience

3 weeks ago

Bengaluru, Karnataka, India Syngene International Limited Full time
Job Description

JOB DESCRIPTION

Designation: Research Investigator (7-I) / Senior Research Investigator (7-II)

Job Location: Bangalore

Department: In vitro Pharmacology - Neuroscience, LDO

About Syngene

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.

Job Purpose (1-2 Lines)

BBRC is seeking an experienced scientist (PhD) with expertise in Neuroscience to join their Molecular Pharmacology group in their mission of discovery and validation of therapeutic targets and participation in drug discovery programs. Applicants with expertise in neurodegenerative diseases like Alzheimers/Multiple Sclerosis etc and other neurological conditions are particularly encouraged to apply.

Key Responsibilities:

- Perform patch-clamp electrophysiology/field potential recordings/MEA etc on brain slices, primary neurons/human iPSCs aimed at execution of discovery programs focused on neurodegenerative diseases
- Deliver high quality data to support identification/development of novel targets/candidate selection
- Develop, optimize and perform rigorous ephys/cellular assays to support the neuroscience therapeutic area
- Culture iPSC-derived cell-types related to your neurological models and primary culture of CNS cell types
- Independently determine in-vitro pharmacologic methods and procedures to study modulation of GPCRs/neurotransmitter receptors in brain slices/primary neurons/human iPSC neurons etc
- Develop and troubleshoot assays independently, record, analyze and communicate scientific data; ensure the accuracy and reliability of data
- Search and review the scientific literature independently on the target biology

Educational Qualification: PhD in Neuroscience or related discipline

Experience: 1-5 years

Technical/functional Skills:

- Demonstrated technical proficiency in ephys assays (patch-clamp/extracellular field potential recordings/MEA etc on brain slices), obtaining healthy hippocampal slices/brain slice preparation from rat/mouse brain
- Experience in neuropharmacology/small molecule pharmacology at therapeutically relevant GPCRs/neurotransmitter receptors at the molecular level in the CNS
- Hands-on experience in complex cellular models/ex-vivo systems, including designing and executing mechanistic/pharmacological characterization of lead candidates
- Must be independent and able to follow pre-established experimental designs, as well as develop new methods, protocols, and technologies based on existing literature

Behavioral Skills: Strong problem-solving and data analysis skills, excellent written and verbal communication skills, good presentation skills, and the ability to handle multiple projects simultaneously and meet aggressive project timelines. Must demonstrate integrity and take accountability for their work

Equal Opportunity Employer:

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.

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