▷ Urgent Formulation R&D

4 days ago


Hyderabad India Promea Therapeutics Full time

Job Description Job Responsibilities - Formulation Design & Development - Design and develop robust, scalable formulations for oral solid dosage forms (OSDs) including tablets, capsules, and granules. - Select appropriate excipients, processing techniques (e.g., direct compression, wet/dry granulation), and equipment. - Develop formulations that meet target product profiles (QTPP), including bioavailability, stability, and manufacturability. - Pre-formulation & Compatibility Studies - Conduct pre-formulation studies to evaluate properties such as solubility, hygroscopicity, flow, and compressibility. - Perform drugexcipient compatibility studies using thermal and analytical methods (e.g., DSC, FTIR). - Experimental Batch Execution - Plan, execute, and supervise laboratory-scale, exhibit, and pilot batches. - Operate and troubleshoot equipment like blenders, granulators, tablet compression machines, capsule fillers, and coating pans. - Ensure compliance with cGMP during batch execution. - Process Development & Optimization - Optimize manufacturing processes using tools such as QbD and DoE. - Establish process parameters and critical process attributes (CPAs, CPPs). - Evaluate scalability and reproducibility for commercial manufacturing. - Stability Studies - Design and initiate stability studies as per ICH guidelines. - Coordinate with the analytical department for timely sample analysis and review of results. - Monitor product behavior under different storage conditions and recommend formulation/process changes if needed.



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