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Post Doctoral Fellow

3 months ago

Rajarhat Kolkata West Bengal, India Tata Medical Center Full time

**Add Validity: 10/4/2024**

**Position**:Postdoctoral Fellow

**No. of positions**:1

**Appointing Organisation**:Tata Translational Cancer Research Centre

Tata Medical Center, Kolkata

**The Tata Medical Center and the Tata Translational Cancer Research Centre**

The Tata Medical Center (TMC) is a multispecialty institution for tertiary cancer care based in New

Town, Kolkata. At TMC, clinical and research activities are integrated to provide state-of-the-art care

for patients with cancer. This integration is enabled by the Tata Translational Cancer Research

Centre (TTCRC), the research arm of TMC. TTCRC is within a dedicated academic space and spread

over 3 floors. At TTCRC, a multidisciplinary team of clinicians, scientists, academics and industry

professionals collaborate to develop a systems medicine approach in cancer research. This approach

is focussed on developing innovative, indigenous, cost-effective and equitable strategies to improve

cancer diagnosis; develop treatments that match disease characteristics and are adapted to

treatment response; and, identify prognostic and predictive disease biomarkers. These strategies are

multi-dimensional and involve an iterative pathway that include clinical studies, high-throughput

laboratory investigations, computational strategies to integrate, analyse and model data, hypothesis
- based pre-clinical studies and evidence-based translation of findings to clinical practice. For

**The Position and the PReDiCT research group**

Applications are invited for the position of Postdoctoral fellow within **P**ersonalised **Re**sidual **Di**sease

**T**racking in **C**ancer (PReDiCT) group at TTCRC. PReDiCT group is focussed on tracking mínimal

residual disease (MRD) in Acute Lymphoblastic Leukemia (ALL) patient and work in an integrated

fashion with the clinical Genomics team at TTCRC. We employ genomic methods to identify patient

specific targets. These targets are then tracked to measure the disease burden in the follow up time

points after each phase of treatment. This work has a great translational impact and helps in clinical

decision making for the patients’ treatment. The group is internationally accredited for the mínimal

residual disease detection in childhood ALL by RQ-PCR method. PReDiCT group is dedicated in two

different activities: (a) Prospective MRD monitoring in ALL patients and (b) implementation of NGS

based workflow for MRD monitoring. The group has a dedicated laboratory facility equipped with

Illumina, Sanger and Nanopore sequencers and it facilitates several national and international

collaborative studies. The group is supported by a dedicated clinical research unit and biorepository

unit (TiMBR) at TTCRC.

TiMBR Team. Primary responsibility will be to maintain good laboratory practices and perform,

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oversee the prospective RQ-PCR MRD workflow, evaluate and report the patients on time to CRU

unit. Details of the responsibilities includes:
(a) Identifying patients for RQ-PCR MRD

(b) DNA extraction of patient’s samples and QC for MRD workflow

(c) Tracking MRD for ALL patients highlighted by CRU

(d) Analysis and reporting the MRD results on time

(e) Proper documentation of regular experiments

(f) Taking part in the quality assessment (QA) twice a year organised by Euro MRD consortium

(g) Active participation in data presentations in group meetings and journal club.

(h) Collating data, creating publication standard figures and contributing in manuscripts

preparation.

**Minimum required qualifications/experience**

(a) PhD (submitted) in Biological Sciences with expertise** **in Molecular Biology and Genomics

(b) Hands-on experience in basic laboratory protocols and techniques like DNA extraction, quality

check, qPCR, sequencing (Sanger and/or next generation sequencing)

(c) Soft skills: MS Office, Laboratory and clinical data management

(d) Competency in managing large data, data analysis and familiarity with statistical analysis

softwares and GraphPad Prism.

**Additional experience**
- Exposure in handling patients’ samples
- prior experience (1-2 years) in Sanger Sequencing
- Library preparation on Illumina platform is preferred but not mandatory.

**Necessary qualities**

(a) Integrity, motivation, enthusiasm, responsibility and reliability

(b) Focus and commitment in carrying out tasks and duties

(c) Critical analytical and problem-solving skills, capable of independent work

(d) Ability to work effectively as part of a multidisciplinary team

**Appointment and reporting**

Appointment to the position will initially be for 3 (three) years. The first year is probationary.

of performance through periodic appraisals. The consolidated monthly salary would be

the group lead and will report to the PReDiCT group lead (Dr. Pritha Dasgupta) at TTCRC.

**Enquiries**

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**Mr Suvasish Mukherjee**

Head, Human Resources

Tata Medical Center, Kolkata 700 160

**and**