Research Assistantship in Clincial Proteomics

**Research Assistantship(RA) at the TTCRC Clinical Proteomics Unit**

**Appointing Organisation**

Tata Translational Cancer Research Centre

Tata Medical Center, Kolkata

**Last Date of Application:16/09/2023
**The Tata Medical Center and the Tata Translational Cancer Research Centre**

The Tata Medical Center (TMC) is a multispecialty institution for tertiary cancer care based in

New Town, Kolkata. At TMC, clinical and research activities are integrated to provide state-of
- the-art care for patients with cancer. This integration is enabled in the Tata Translational Cancer

Research Centre (TTCRC), the research arm of TMC. TTCRC is within a dedicated academic

space and spread over 3 floors. At TTCRC, a multidisciplinary team of clinicians, scientists,

academics, and industry professionals collaborate to develop a systems medicine approach in

cancer research. This approach is focussed on developing innovative, indigenous, cost-effective

and equitable strategies to improve cancer diagnosis; develop treatments that match disease

characteristics and are adapted to treatment response; and, identify prognostic and predictive

disease biomarkers. These strategies are multi-dimensional and involve an iterative pathway that

include clinical studies, high-throughput laboratory investigations, computational strategies to

integrate, analyse and model data, hypothesis-based pre-clinical studies and evidence-based

translation of findings to clinical practice.

**The opportunity at TTCRC Clinical Proteomics Unit**

We offer a Research Assistantship position to train you on handling liquid chromatography

coupled to mass-spectrometry (LC-MS/MS) instrument. In this position you will work as part of

the proteomics team at TTCRC. The group’s work is focussed currently on two aspects, 1.

developing plasma proteomics and biomarker discovery platform in both solid cancer and

Leukaemia. 2. providing proteomics solutions to other in-house clinical research teams where you

is supported by a dedicated tissue biorepository, a clinical research unit, genomics and informatics

analyses. Access to resources include confocal microscopy, flow cytometry, dedicated tissue

culture facility, virus transduction facility and mass spectroscopy. Your primary responsibility will

be understanding the working of the Clinical Proteomics Unit. It’ll include troubleshooting,

optimizing and maintaining the working of the LC-MS/MS instrument; as well as developing,

testing and standardizing various sample preparation and purification techniques. It’ll be a regular

activity to aid other groups in their requirements for processing samples through the proteomic

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pipeline and as well in supporting with the data analysis. You’ll be expected to understand the

biology of the drug mechanisms in cellular environment.

**Minimum required qualifications/experience**

MSc/M. Tech in Biological Sciences, including Life Sciences, Genetic Engineering,

Biotechnology, Cell & Molecular Biology, and Microbiology.

Hands-on experience with molecular biology techniques like Protein purification, Gel

Electrophoresis, Western Blotting, etc.

**Desirable Experience**: Prior experience (1-2 years) in Proteomics/ Protein extraction,

purification, Gel electrophoresis, Liquid Chromatography like HPLC, FPLC etc.

Prior exposure to LC-MS/MS system is preferred but not mandatory

Familiarity with basic theory of Mass-Spectrometry and Protein Biology is essential.

**Necessary qualities**

(a) Integrity, motivation, enthusiasm

(b) Focus and commitment in carrying out tasks and duties

(c) Critical analytical and problem-solving skills, capable of independent work

(d) Ability to work effectively as part of a multidisciplinary team

(e) Clarity in career and professional development goals

**Appointment and reporting**

to satisfactory review of performance at the end of the tenure. The monthly remuneration would be

according to the TTCRC policy. The successful applicant will be managed by the Team Lead,

Clinical Proteomics Unit and will report to the Director, TTCRC.

**Enquiries**

Mr Suvasish Mukherjee; Head, Human Resources; Tata Medical Center; 14 Major Arterial

Road (East-West); Newtown, Rajarhat; Kolkata 700 160

(c) For informal enquiries,

1) Dr. Trina Dutta, Post-Doctoral Fellow, Clinical Proteomics Unit, TTCRC-TMC.

2) Mr. Satadru Dey, Administrative Assistant, TTCRC-TMC.

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