Post Doc Fellow

2 weeks ago

Rajarhat Kolkata West Bengal, India Tata Medical Center Full time

**Position: Post-Doctoral Fellow in Genomics**

**No. of positions: 1**

**Validity: 6/4/2024**

**Appointing Organisation**

Tata Translational Cancer Research Centre

Tata Medical Center, Kolkata

**The Tata Medical Center and the Tata Translational Cancer Research Centre**

The Tata Medical Center (TMC) is a multispecialty institution for tertiary cancer care based in

New Town, Kolkata. At TMC, clinical and research activities are integrated to provide state-of
- the-art care for patients with cancer. This integration is enabled by the Tata Translational Cancer

Research Centre (TTCRC), the research arm of TMC. TTCRC is within a dedicated academic

space and spread over 3 floors. At TTCRC, a multidisciplinary team of clinicians, scientists,

academics and industry professionals collaborate to develop a systems medicine approach in

cancer research. This approach is focussed on developing innovative, indigenous, cost-effective

and equitable strategies to improve cancer diagnosis; develop treatments that match disease

characteristics and are adapted to treatment response; and, identify prognostic and predictive

disease biomarkers. These strategies are multi-dimensional and involve an iterative pathway that

include clinical studies, high-throughput laboratory investigations, computational strategies to

integrate, analyse and model data, hypothesis-based pre-clinical studies and evidence-based

translation of findings to clinical practice. For additional information on work at TTCRC, visit

**The Position**

group works in close association with the department of cytogenetics at TMC as well as with the

clinical research unit (CRU) and biobank in TTCRC. It provides core sequencing facility for other

TTCRC research groups like - FORE and SOLi3D. Since its inception in 2018, it has established

Illumina-based platforms for RNA-Seq, targeted panel sequencing and single nucleotide

polymorphism analyses (for copy number alterations). Recently it has expanded its sequencing

capacity to the Oxford Nanopore Technology (ONT) platform. Output of the Genomics lab

complements standard diagnostics in ALL patients treated at TMC and therefore building up a

workflow for setting up the pipeline for companion diagnostics. We are working with St Jude

Children’s Research Hospital (SJCRH), Memphis to develop a common RNAseq-based classifier

for the ICiCLe network, which can be used internationally. This project is named “Diagnostic

Innovations Using Value-Based Implementation Models to Increase Access” or DIVIA and is

funded by SJCRH. While the Illumina-based approach is a gold-standard, we are working with a

team at University of North Carolina (UNC), Chapel Hill to develop a cost-effective, ONT-based

approach, using the same samples sequenced on the Illumina platform. This project, Diagnostic

Applications in Resource Limited Settings Using Global Advances in Nanopore Technologies

Page **1** of **3**

(DARGAN) has been pump-primed by a grant from University of North Carolina, Chapel Hill.

based workflow in TTCRC and acting as a primary point of contact for coordinating the ongoing

of the high through-put genomics workflows which would include planning, execution and

optimisation of experimental protocols for bulk and single-cell transcriptome sequencing, ATAC
- Seq and methylation assays as well as trouble shooting and data analysis. This will also involve

working closely with hospital’s multidisciplinary team of clinician and technicians, and with

mentoring skills to train and motivate freshers or juniors and should also demonstrate some

essential skills including good communication, problem-solving, decision-making, critical thinking,

emotional intelligence, and ethical awareness.

**Minimum required qualifications/experience**

(a) PhD in Biological Sciences with at least 2 years of experience working in wet-lab

(b) Experience with DNA and RNA-based workflows in genomics

(c) Strong awareness about good laboratory practices and guidelines

(d) Good Team Player

(e) Independent decision-making capability

**Necessary qualities**

(a) Integrity, motivation, enthusiasm

(b) Focus and commitment in carrying out tasks and duties

(c) Clarity in career and professional development goals

**Appointment and reporting**

Appointment to the position will be initially for 3 (three) years including one year of probationary

period. The consolidated starting monthly salary is negotiable based on qualifications and

experience. The position is funded by a core CSR grant from the Tata Consultancy Services. The

successful applicant will be managed by the Group Lead in Genomics and will report to the

Director.

**Enquiries**

**Mr Suvasish Mukherjee**; Head, Human Resources; Tata Medical Center; 14 Major Arterial Road (East
- West); Newtown, Rajarhat; Kolkata 700 160

Page **2** of **3**

**Mr. Satadru Dey; **Administrative Assistant, Tata Translational Cancer Research Centre***
Tata Medical Centre
- Kol

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