Upstream Process Development Scientist

2 weeks ago

Bengaluru, India Syngene Full time

Job Title: Upstream Process Development Scientist

Job Location: Bangalore

We're looking for an Upstream Process Development Scientist with 2-5 years of experience to join our team. In this role, you'll be crucial in developing and optimizing upstream processes for the production of large molecules, including monoclonal antibodies (mAbs) and biosimilars.

If you have a strong background in handling CHO cells and experience with cutting-edge bioreactor systems, we encourage you to apply

Responsibilities:

  • Design, execute, and analyze experiments for the development and optimization of upstream cell culture processes, focusing on CHO cell lines.
  • Work with large molecules, including monoclonal antibodies (mAbs) and biosimilars, throughout the process development lifecycle.
  • Operate and troubleshoot various bioreactor systems, including AMBR250, Single-Use Bioreactors (SUBs), and 10L reactors.
  • Optimize cell culture media, feeding strategies, and process parameters to maximize yield and product quality.
  • Analyze process data, interpret results, and present findings to the team.
  • Contribute to the transfer of developed processes to manufacturing.
  • Maintain detailed and accurate documentation of all experimental work.
  • Stay current with industry trends and advancements in upstream process development.

Qualifications:

  • Master's in Chemical Engineering, Biotechnology, Bioengineering, or a related scientific discipline.
  • 3-6 years of hands-on experience in upstream process development within the biopharmaceutical industry.
  • Demonstrated expertise in handling and culturing CHO cells.
  • Proven experience with large molecule production, specifically monoclonal antibodies (mAbs) and biosimilars.
  • Hands-on experience operating and troubleshooting AMBR250, Single-Use Bioreactors (SUBs), and 10L reactors.
  • Strong understanding of cell culture principles, bioreactor operations, and process scale-up.
  • Excellent data analysis, troubleshooting, and problem-solving skills.
  • Ability to work independently and collaboratively in a fast-paced environment.
  • Strong written and verbal communication skills.

Bonus Points if You Have:

  • Experience with Design of Experiments (DoE) software and statistical analysis.
  • Knowledge of GMP principles and regulatory guidelines

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