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Execution and purification of different vaccine bulk (Dengue Vaccine, Hepatitis A Vaccine and E.Coli, BPBC /CEPI Vaccine).Planning, supervision & execution of overall purification related activities.Development of individual unit operation (Cell Lysis, Clarification & chromatography) to final Drug substance of different vaccine.In process sampling during batch processing.Sterile filtration of bulk drug substance.Quality management system (Filling of incident, raising deviation, change control, CAPA and other quality system).Proper training and enhance the overall capabilities of subordinates.Preparation of SOPs, BPRs, protocol report and other documents required for downstream activities.IQ, OQ and PQ of new equipment’s to be installed in downstream processing area.Execution of Revalidation of refrigerated incubators, refrigerators and tank system according to established schedule.Execution of In –House Calibration of AKTA System, spectrophotometer, Auto pipettes, Weighing balance and pH /conductivity meter.Data compilation and data analysis.Preventive maintenance of equipment in downstream processing area, Proper working of equipment’s and other ancillary items in DSP.Compliance of the area and equipment as per R&D, GLP and GMP norms.Prioritization of tasks and completion of those in a timely manner.Any other responsibilities as assigned by R&D Head.